Finding causes of unexplained repeated early miscarriages
Official title: Cohort of Patients Presenting Unexplained Recurrent Miscarriages and Identification of Early Miscarriage Recidivism Factors
Run by Assistance Publique - Hôpitaux de Paris · NCT05557201 · Data updated 2026-11-12
This project will collect medical and biological data from women aged 18–50 who have had three or more early miscarriages or repeated implantation failures to try to find factors linked to repeat pregnancy loss.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | Women only |
| Enrollment | 700 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | October 24, 2022 |
| Main results expected | October 2027 |
| Study ends | October 2029 |
| Registry record updated | December 19, 2025 |
| Trial ID | NCT05557201 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 18–50 with at least three early pregnancy losses before 14 weeks of amenorrhea or at least three implantation failures who consent to use of their medical data and have social security coverage.
✕Probably not a fit
Patients with a clearly identified and unavoidable cause of miscarriage (for example a known parental chromosomal abnormality), those under legal protection, or those who do not consent to data use are unlikely to benefit from this observational data collection.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational cohort of patients presenting with recurrent early pregnancy loss or repeated implantation failure who will be followed as part of routine care at a single center. On inclusion, investigators will record detailed medical, obstetric, lifestyle and demographic histories and compile data for each prior pregnancy, including outcomes and treatments. Biological samples and standard laboratory tests (including screening for antiphospholipid, antithyroid and other antibodies) will be collected or reviewed when available to search for prognostic factors. No experimental interventions are given; participants continue usual clinical care while their data are analyzed to identify patterns linked to recurrence.
Why it matters
Potential benefit: If successful, the findings could help identify immune, genetic or other risk factors so clinicians can offer more targeted testing and tailored management to reduce future miscarriages.
How similar studies have gone: Previous observational work has identified some immune and genetic contributors to recurrent miscarriage but about half of cases remain unexplained, so this project builds on existing findings to seek additional prognostic markers.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 to 50 years * Patients who have had 3 (or more) early pregnancy losses occurring before 14 weeks of amenorrhea and/or at least 3 implantation failures. * Patients who have been informed and have not objected to participating in the study. * Patients covered by a social security system. Exclusion Criteria: * patients who do not agree the use of their data * Patients on AME * Patients under legal protection
Where it's running
-
Internal medicine department, hospital Saint Antoine
Paris, France Recruiting
Study contacts
- Principal investigator: Arsene MEKINIAN, MD, PhD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Arsene MEKINIAN, MD, PhD
- Email: arsene.mekinian@aphp.fr
- Phone: 1 71 97 07 65
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.