Finding causes of allergic reactions during and after surgery
Official title: Diagnosis and Allergen Identification of Perioperative Anaphylaxis: a Multicenter Prospective Cohort Study
Run by Peking University First Hospital · NCT06793163 · Data updated 2026-11-12
This project tests whether measuring tryptase levels and doing skin tests can find the cause of suspected allergic reactions during or after surgery for patients aged 2 and older.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 2 Years and up |
| Sex | All |
| Enrollment | 115 (estimated) |
| Sponsor | Peking University First Hospital Academic / other |
| Locations | 6 sites (Beijing, Beijing Municipality and 5 other locations) |
| Status | Recruiting |
| Started | January 25, 2025 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | June 18, 2026 |
| Trial ID | NCT06793163 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Surgical patients aged 2 years or older who experienced a suspected allergic reaction in the operating room or perioperative period are the intended participants.
✕Probably not a fit
People without suspected perioperative allergic reactions, those unable or unwilling to undergo blood draws or delayed skin testing, or reactions not driven by an allergic mechanism are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective cohort across several Beijing hospitals enrolling surgical patients with suspected perioperative anaphylaxis. Blood samples for serum tryptase are collected as soon as possible after the event and repeated about 24 hours later, and skin prick and intradermal tests are performed 4–6 weeks afterward to identify specific allergens. The study quantifies the rate of perioperative anaphylaxis and links tryptase dynamics to confirmed allergen sensitization. Patients who refuse or are judged unsuitable for participation are excluded.
Why it matters
Potential benefit: If successful, the approach could help clinicians more reliably diagnose perioperative anaphylaxis and identify offending drugs or agents so they can be avoided in future procedures.
How similar studies have gone: Measuring serum tryptase and performing skin prick/intradermal tests are established diagnostic tools with supporting evidence, though prospective cohorts focused on perioperative cases are relatively limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 2 years or over; * Suspected anaphylaxis in the operating rooms, or history of suspected anaphylaxis in the operating room. Exclusion Criteria: * Refuse to participate; * Other conditions that are considered unsuitable for study participation.
Where it's running
-
Peking University First Hospital
Beijing, Beijing Municipality, China Recruiting -
Beijing Anorectal Hospital (Beijing Erlong Road Hospital）
Beijing, Beijing Municipality, China Recruiting -
Beijing Children's Hospital, Capital Medical University; National Center for Children's Health, China
Beijing, Beijing Municipality, China Recruiting -
Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, China Recruiting -
Peking University First Hospital
Beijing, Beijing Municipality, China Recruiting -
Beijing Tongren Hospital, Capital Medical University
Beijing, Beijing Municipality, China Not yet recruiting
Study contacts
- Principal investigator: Dong-Xin Wang, MD, PhD — Peking University First Hospital
- Study coordinator: Dong-Xin Wang, MD, PhD
- Email: wangdongxin@hotmail.com
- Phone: 86-10-83572784
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.