FES-PET/MRI to tailor treatment for Luminal A and ER-positive lobular breast cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, prospective cohort study enrolling women with Luminal A or ER-positive lobular breast cancer to undergo FES-PET/MRI imaging before primary surgery. The goal is to assess how well FES-PET/MRI can stage axillary disease compared with surgical axillary staging. The study also explores biological factors that contribute to tumor heterogeneity. Interventions include FES, PET/MRI imaging, and translational analyses on collected samples.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female patients, age\>= 18 yrs, diagnosed with primary or advanced breast cancer
* LumA or ER-positive Lobular subtypes

  * candidates to surgery as first treatment regardless of cN
  * ER-positive Her2 negative BC with ki67\>10%

Exclusion Criteria:

* ER-negative tumors
* Pregnancy;
* Contraindication to PET;
* Contraindication to MRI;
* Claustrophobia;
* Allergy to the MR contrast agent;
* Severe renal insufficiency

Where it's running

• IRCCS Ospedale San Raffaele
  Milan, Mi, Italy Recruiting

Study contacts

• Study coordinator: Rosa Di Micco, MD
• Email: dimicco.rosa@hsr.it
• Phone: +39022643

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.