Fertility-preservation decision aid for parents and adolescent and young adult cancer survivors
Official title: A Double Blind Randomised Controlled Trial of a Paediatric Fertility Preservation Decision Aid in Parents and Adolescents and Young Adults (CAYA) Cancer Survivors
Run by Murdoch Childrens Research Institute · NCT06894810 · Data updated 2026-11-12
This research tests whether adding a fertility preservation decision aid to standard information helps parents and adolescent and young adult cancer survivors better meet their fertility information needs.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 16 Years and up |
| Sex | All |
| Enrollment | 358 (estimated) |
| Sponsor | Murdoch Childrens Research Institute Academic / other |
| Locations | 1 site (Melbourne, Victoria) |
| Status | Recruiting |
| Started | December 8, 2025 |
| Main results expected | June 2027 |
| Study ends | June 2027 |
| Registry record updated | October 16, 2026 |
| Trial ID | NCT06894810 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
English-speaking parents/guardians of CAYA survivors diagnosed at age ≤25 and CAYA survivors aged 16 years or older who have completed curative gonadotoxic cancer treatment are ideal candidates.
✕Probably not a fit
Patients currently undergoing cancer treatment, those receiving palliative care, non-English speakers, minors not deemed mature per protocol, and family members already enrolled are excluded and unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a parallel-group, double-blind randomized controlled trial comparing standard high-quality information alone versus the same information plus a Fertility Preservation Decision Aid (FP DA) for parents and CAYA cancer survivors. Eligible participants are English-speaking parents of survivors diagnosed at age 25 or younger and survivors aged 16 or older who have completed curative gonadotoxic treatment. Participants are randomized to one of the two arms and instructed to review their assigned materials while blinded to allocation; primary outcomes include unmet fertility information needs, understanding of fertility status, and decision-making about fertility testing, storage, and use of gametes. The study is run at Murdoch Children's Research Institute in Melbourne with University of Melbourne collaboration.
Why it matters
Potential benefit: If successful, the decision aid could improve survivors' and parents' understanding of fertility risks and options and reduce missed opportunities for preservation or timely decision-making.
How similar studies have gone: Decision aids have shown benefits in other medical decision contexts, but their specific use for fertility information in cancer survivorship is novel and evidence is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Inclusion Criteria for both parents and survivors: * Be able to communicate in English. * Signed written informed consent form. Inclusion Criteria for parents only: • Parents/guardians of CAYA survivors who were ≤25 years (2) when diagnosed with cancer and have completed curative gonadotoxic treatment Inclusion Criteria for survivors only * CAYA cancer survivors aged 16 years or over who have completed curative gonadotoxic treatment. * Participants can be on long-term adjuvant or endocrine therapy. * Participants may have achieved a pregnancy or livebirth. Exclusion Criteria: Exclusion Criteria for both parents and survivors: * CAYA patients currently undergoing cancer treatment and their parents/guardians. * CAYA patients who are palliative and their parents/guardians * A family member already in the study. Exclusion Criteria for survivors only: • Minors who are not deemed to be mature minors as per protocol
Where it's running
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Murdoch Children's Research Institute
Melbourne, Victoria, Australia Recruiting
Study contacts
- Study coordinator: Diana Navarro-Perez, PhD
- Email: d.navarroperez@unimelb.edu.au
- Phone: +61 03 8345 3721
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.