Fentanyl versus morphine for sedation and pain control in adults on mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults in the ICU who need invasive mechanical ventilation and continuous infusion sedation within 12 hours of admission are randomized to receive either fentanyl or morphine together with propofol. The proportion of patients reaching the target sedation score at 12 and 24 hours and the proportion requiring rescue sedation doses are recorded. Duration of mechanical ventilation, length of ICU stay, and 14-day mortality are also compared between the two groups. Patients with chronic opioid use, severe liver or end-stage renal failure, pregnancy, neuromuscular blockade, severe neurocognitive dysfunction, drug overdose, known allergy to the drugs, or severe traumatic brain injury are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>18 years old
* Patients who are expected by the ICU team to require invasive mechanical ventilation in ICU for at least more than 24 hours and for whom the ICU team decides to initiate continuous infusion of sedation
* A patient who was ventilated and sedated not more than 12 hours before ICU admission.

Exclusion Criteria:

* Patients with chronic use of narcotics
* Patients with chronic liver failure or end-stage renal failure
* Patients with severe chronic neurocognitive dysfunction
* Patients with drug overdose
* Patients with a known allergy to either morphine or fentanyl
* Patients who are receiving neuromuscular blockers
* Patients who are pregnant
* Patients who are diagnosed to have severe traumatic brain in

Where it's running

• Hospital Universiti Sains Malaysia
  Kota Bharu, Kelantan, Malaysia Recruiting

Study contacts

• Study coordinator: Mohd Zulfakar Mazlan Dr, MBBS
• Email: zulfakar@usm.my
• Phone: +60135335566

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.