Feasibility test of CPAP for large airway collapse

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This feasibility study investigates CPAP as a potential treatment for adults with large airway collapse (LAC), including those with asthma. Participants must have confirmed LAC and have had at least one recent exacerbation of their respiratory disease. The trial will assess safety and practicality of CPAP use in this population, alongside typical care for coexisting respiratory conditions. Results will inform whether a larger, more definitive trial is warranted. The study is sponsored by the Liverpool School of Tropical Medicine with involvement from Royal Liverpool University Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria

1. Adult (≥18 years) at visit 1
2. Able to provide informed consent
3. Prior confirmation of LAC (diagnosed either radiographically or with bronchoscopy)
4. Respiratory co-morbidities optimised
5. ≥1 course of antibiotics and/or prednisolone for an exacerbation of chronic airway disease in the preceding 12 months before visit 1.

Exclusion Criteria

1. Contraindication to CPAP as per British Thoracic Society (BTS) guidelines
2. Already using domiciliary CPAP (including privately purchased)
3. Known obstructive sleep apnoea syndrome (OSAS) eligible for CPAP
4. Suspected OSAS that is awaiting further investigation
5. Pregnant or planning a pregnancy in the next 12 months

Where it's running

• The Royal Liverpool Hospital
  Liverpool, United Kingdom Recruiting

Study contacts

• Study coordinator: Rebecca Nightingale Dr Nightingale, PhD
• Email: rebecca.nightingale@lstmed.ac.uk
• Phone: +441517053100

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.