Fat-derived cell treatment for thin uterine lining and intrauterine adhesions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 1 interventional trial enrolls women with refractory thin endometrium (<6 mm) or moderate to severe intrauterine adhesions who desire pregnancy. Participants undergo liposuction to obtain adipose tissue, from which adipose-derived stromal vascular fraction (AD-SVF) is isolated and infused into the uterine cavity. Patients are followed for six months to record changes in menstrual volume, endometrial thickness, and any early pregnancy outcomes, with repeat hysteroscopy if clinically indicated. The single-center trial at the Affiliated Nanjing Drum Tower Hospital focuses on initial safety and early signals of efficacy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. refractory thin endometrium (endometrial thickness \< 6 mm on the day of ovulation or the day of endometrial transformation during a hormone replacement cycle) and/or moderate to severe intrauterine adhesion；
2. Inability to undergo autologous bone marrow stem cells-scaffold (BMSC) transplantation due to failed bone marrow aspiration, or lack of significant effect following the BMSC treatment;
3. with fertility intentions;
4. normal ovarian function or availability of cryopreserved embryos;
5. 18kg/m\^2 \< body mass index (BMI) \< 30kg/m\^2;

Exclusion Criteria:

1. Chromosomal karyotype abnormalities in one spouse;
2. Severe endometriosis, uterine fibroids affecting the uterine cavity morphology, or uterine malformations;
3. Abnormalities in coagulation function, hepatic or renal function, or other underlying conditions deemed by the investigator to potentially impact the study's progression (uncontrolled hypertension, diabetes, autoimmune diseases, etc.);
4. Contraindications for pregnancy;
5. Contraindications for hormonal cycle therapy;
6. History of pelvic tumors;
7. Simultaneous participation in other clinical studies.

Where it's running

• Nanjing Drum Tower Hospital
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Principal investigator: Yali Hu — The Affiliated Drum Tower Hospital of Nanjing University
• Study coordinator: Yali Hu
• Email: glyyhuyali@163.com
• Phone: 86-025-83106666

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Effects of HMB supplementation on muscle recovery after knee surgery in female athletes

  This study is testing if a supplement called caHMB can help female athletes recover better and keep their muscle strength after knee surgery.

  Recruiting Phase 2 University of Kansas Medical Center · Overland Park, Kansas · NCT05869812

• Improving physical performance in older hospitalized patients through personalized nutrition and exercise

  This study is testing if personalized nutrition and exercise can help older patients in the hospital improve their physical performance and stay active after they go home.

  Recruiting Radboud University Medical Center · Nijmegen, Gelderland · NCT05413616

• Minimally invasive procedure for sinus lift using interradicular access

  This study tests a new, less invasive way to lift the sinus membrane to help people get dental implants while reducing recovery time and discomfort.

  Recruiting Universidad de Murcia · Murcia · NCT05237570

• A modified technique for sinus floor elevation in patients with limited bone height

  This study tests a new, less invasive surgery for people with low bone height to see if it can create enough space for dental implants while also making the experience less stressful for patients.

  Recruiting Medical University of Vienna · Vienna · NCT02137824

• Tributyrin for PSP: a virtual, early-phase study

  This study tests whether tributyrin is safe and tolerable in people with Progressive Supranuclear Palsy who are 45 or older, using virtual visits.

  Recruiting Phase 1/2 University of Michigan · Ann Arbor, Michigan · NCT07863180

• Natural history of atypical parkinsonian syndromes: a multi-center observation

  This study follows people with APS like MSA, DLB, PSP, and CBD to see how their symptoms and brain images change over time.

  Recruiting at 6 sites Second Affiliated Hospital of Soochow University · Changshu, Jiangsu and 19 other locations · NCT07805967

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.