Faster tooth movement using alveolar decortication plus concentrated growth factor (CGF) injection

Impact of Alveolar Decortication Combined With CGF Injection on Acceleration of Maxillary Canine Retraction-A Randomized Clinical Trial

This study will try combining alveolar bone decortication with concentrated growth factor (CGF) injections to speed up canine retraction in 16–22-year-olds who need maxillary first premolar extractions.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 24 (estimated)
• Ages: 16 Years to 22 Years
• Sex: All
• Sponsor: Tanta University (other)
• Locations: 1 site (Tanta, Tanta)
• Trial ID: NCT06975358 on ClinicalTrials.gov

What this trial studies

This interventional study compares alveolar decortication combined with CGF injection versus standard canine retraction without surgical acceleration in patients requiring extraction of the maxillary first premolars. Eligible participants are 16–22 years old with malocclusions that require maxillary premolar extraction and maximum anchorage for canine retraction, and who have good oral hygiene and periodontal health. The procedure involves a surgical decortication of the alveolar bone on the maxillary segment plus local injection of concentrated growth factor, with clinical measurement of the rate of tooth movement over the orthodontic treatment period. Outcomes will focus on speed of canine retraction and related periodontal safety measures.

Who should consider this trial

Good fit: Ideal candidates are 16–22-year-olds who need extraction of the maxillary first premolars and canine retraction with maximum anchorage and who have good oral hygiene and healthy periodontium.

Not a fit: Patients who are medically compromised, have severe maxillary crowding, take chronic NSAIDs or other drugs that interfere with tooth movement, or who had prior orthodontic treatment are unlikely to benefit from this approach.

Why it matters

Potential benefit: If successful, the technique could shorten orthodontic treatment time by accelerating tooth movement.

How similar studies have performed: Previous clinical and preclinical work on decortication and on platelet-derived growth products has shown some promise for accelerating tooth movement, but evidence is still limited and not uniformly conclusive.

Eligibility criteria

Inclusion Criteria:

1. Age of the patients ranged from 16: 22 years old.
2. Malocclusion that requires extraction of the maxillary first premolar and canine retraction (e.g. class I bimaxillary dentoalveolar protrusion and class II div 1 malocclusion).
3. Maximum anchorage needed for the maxillary arch as a part of the orthodontic treatment plan.
4. Good oral hygiene and periodontal condition.

Exclusion Criteria:

1. Medically compromised patients.
2. Severe crowding in the maxillary arch.
3. Chronic intake of NSAIDs or any medication that interfere with OTM.
4. Previous orthodontic treatment.

Where this trial is running

Tanta, Tanta

• Tanta University — Tanta, Tanta, Egypt (RECRUITING)

Study contacts

• Study coordinator: Safa B Alawy, PhD

Conditions: Accelerate Tooth Movement