Faster tooth movement using alveolar decortication plus concentrated growth factor (CGF) injection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares alveolar decortication combined with CGF injection versus standard canine retraction without surgical acceleration in patients requiring extraction of the maxillary first premolars. Eligible participants are 16–22 years old with malocclusions that require maxillary premolar extraction and maximum anchorage for canine retraction, and who have good oral hygiene and periodontal health. The procedure involves a surgical decortication of the alveolar bone on the maxillary segment plus local injection of concentrated growth factor, with clinical measurement of the rate of tooth movement over the orthodontic treatment period. Outcomes will focus on speed of canine retraction and related periodontal safety measures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age of the patients ranged from 16: 22 years old.
2. Malocclusion that requires extraction of the maxillary first premolar and canine retraction (e.g. class I bimaxillary dentoalveolar protrusion and class II div 1 malocclusion).
3. Maximum anchorage needed for the maxillary arch as a part of the orthodontic treatment plan.
4. Good oral hygiene and periodontal condition.

Exclusion Criteria:

1. Medically compromised patients.
2. Severe crowding in the maxillary arch.
3. Chronic intake of NSAIDs or any medication that interfere with OTM.
4. Previous orthodontic treatment.

Where it's running

• Tanta University
  Tanta, Tanta, Egypt Recruiting

Study contacts

• Study coordinator: Safa B Alawy, PhD
• Email: safa_basyouny@dent.tanta.edu.eg
• Phone: 0201009088252

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.