Fast- versus slow-absorbing poly(lactide-co-glycolide) sutures after lower wisdom tooth removal
Comparative Analysis of fast-and Slow-absorbable Poly(Lactose-co-glycolide) Sutures in Oral Surgery: a Randomized Controlled Trial.
NA · University of Padova, School of Dental Medicine · NCT07498361
This test compares fast-absorbing and slow-absorbing PLGA sutures to see if they lead to different bacterial contamination and postoperative discomfort for people having lower wisdom tooth removal.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 27 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Padova, School of Dental Medicine (other) |
| Locations | 1 site (Padua, Padua) |
| Trial ID | NCT07498361 on ClinicalTrials.gov |
What this trial studies
Adults scheduled for surgical removal of a lower third molar are randomly assigned to receive either a fast-resorbing or a slow-resorbing poly(lactide-co-glycolide) suture as part of routine wound closure. Sutures are removed at 7 days and sent anonymously to a university microbiology lab to measure microbial contamination. Participants complete a daily diary during the first postoperative week recording pain and analgesic use, and clinical signs such as swelling and inflammation are recorded at follow-up. Standard antibiotic and anti-inflammatory therapy is given as per usual care and no additional invasive procedures are performed.
Who should consider this trial
Good fit: Non-smokers who need surgical removal of a lower third molar, can give informed consent, are not pregnant, and are not on medications affecting bone metabolism.
Not a fit: Smokers, pregnant people, or those taking medications that affect bone metabolism are excluded from the study and would not directly benefit from participation.
Why it matters
Potential benefit: If successful, the results could help clinicians choose sutures that reduce bacterial contamination, lower postoperative discomfort, or avoid a removal visit.
How similar studies have performed: Similar comparisons of absorbable suture types in oral surgery exist and have produced mixed results, with small clinical differences reported and variable findings on microbial colonization.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * non smoker patients * clinical indication to third molar surgical removal * patients who are able to express informed consent Exclusion Criteria: * smokers * pregnant female * subjects treated with medications that affect bone metabolism
Where this trial is running
Padua, Padua
- Hospital Dental Clinic — Padua, Padua, Italy (RECRUITING)
Study contacts
- Study coordinator: Stefano Sivolella, DDS
- Email: stefano.sivolella@unipd.it
- Phone: 049 821 8669
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Poly Sutures, Suture Resorption, Third Molar Surgery, poly sutures, third molar surgery, microbial biofilm, suture resorption