FAPI PET/CT imaging in arrhythmogenic right ventricular cardiomyopathy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, single-group diagnostic imaging study using a protocol-specified 68Ga-DOTA-SA-FAPI PET/CT to image fibroblast activation in patients with established ARVC. Participants are adults under follow-up at the study center who meet 2010 Task Force and/or Padua criteria and who do not have exclusion conditions such as prior malignancy or severe organ impairment. Imaging findings will be compared to conventional assessments such as echocardiography and cardiac magnetic resonance imaging to determine incremental diagnostic information. The study aims to characterize focal or diffuse FAPI uptake patterns that may indicate active myocardial remodeling relevant to arrhythmic risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years or older
* Established diagnosis of arrhythmogenic right ventricular cardiomyopathy according to the 2010 Revised Task Force Criteria and/or the Padua criteria
* Under active follow-up at the study center
* Ability to understand the study procedures and provide written informed consent

Exclusion Criteria:

* History of malignancy
* Severe renal impairment
* Severe hepatic impairment
* Pregnancy or breastfeeding
* Prior 68Ga-DOTA-SA-FAPI PET/CT imaging
* Inability or unwillingness to provide written informed consent
* Any medical, clinical, or logistical condition that, in the opinion of the investigators, could interfere with study participation, image interpretation, or completion of follow-up

Where it's running

• Istanbul University-Cerrahpasa Institute of Cardiology
  Istanbul, Fatih, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Sukru Arslan, MD, Associate Professor
• Email: sukru.arslan@iuc.edu.tr
• Phone: +90 555 623 2606

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• 4D MRI parameters linked to cardiovascular and cancer disease outcomes

  This study tests whether 4D MRI measurements can predict how cardiovascular diseases and cancer will progress in adults undergoing routine cardiac MRI at a single Korean hospital.

  Recruiting Ulsan University Hospital · Ulsan, Ulsan · NCT07678606

• Cardiac MRI blood-flow imaging to distinguish types of hypertrophic cardiomyopathy

  We will try cardiac MRI perfusion imaging to see if blood-flow patterns can distinguish people with different forms of hypertrophic cardiomyopathy, including genetic carriers and related conditions like Fabry disease and cardiac amyloidosis.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, BO · NCT07382128

• 18F‑Pentixafor PET/MR and cardiac MRI to check heart microcirculation after a first heart attack

  This will test whether 18F‑Pentixafor PET/MR plus cardiac MRI can reveal small‑vessel injury and recovery in people who had a first heart attack treated with emergency PCI.

  Recruiting The Affiliated Hospital of Qingdao University · Qingdao, Shandong · NCT07130409

• Faster cardiac MRI using deep-learning image reconstruction to measure left ventricular ejection fraction

  This will test whether a faster cardiac MRI scan using deep-learning reconstruction can accurately measure ejection fraction in adults referred for left ventricular hypertrophy.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07061821

• Multicenter stress cardiac MRI measuring heart muscle blood flow

  This will test whether detailed stress cardiac MRI blood-flow measurements help identify heart-related causes of chest pain or shortness of breath in adults 35–85 with suspected coronary artery disease.

  Recruiting at 13 sites Brigham and Women's Hospital · San Francisco, California and 12 other locations · NCT06854458

• Identifying patients with cardiomyopathy for potential heart transplantation

  This study is trying to find new ways to identify and understand cardiomyopathy in patients to better predict if they might need a heart transplant in the future.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Emilia-Romagna/Bologna and 2 other locations · NCT06813443

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.