Clinical trial Recruiting at 1 site Observational Ages 18 and up

Factors that predict needing rescue ventilation during airway surgery with THRIVE

Official title: Determinants of Rescue Ventilation Requirement in Airway Surgery Under General Anesthesia With Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE): A Prospective Observational Study

Run by Seoul National University Hospital · NCT06925282 · Data updated 2026-11-12

We will test which factors predict needing rescue ventilation in adults having elective airway surgery under general anesthesia with THRIVE.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment80 (estimated)
SponsorSeoul National University Hospital
Academic / other
Locations1 site (Seoul)
StatusRecruiting
StartedApril 25, 2025
Main results expectedMarch 2027
Study endsApril 2028
Registry record updatedApril 24, 2026
Trial IDNCT06925282 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults undergoing elective airway surgery for subglottic stenosis under general anesthesia with THRIVE who can provide written informed consent.

Probably not a fit

Patients who are pediatric, undergoing emergency airway procedures, not managed with THRIVE, or who decline participation are unlikely to benefit from this study's findings.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will record oxygen saturation continuously during elective airway surgeries performed under general anesthesia with Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE). Investigators will note the time point when oxygen saturation falls below 92% and rescue ventilation is initiated. Clinical, anatomical, and anesthesia-related variables (for example age, severity of subglottic stenosis, anesthesia technique, and apnea duration) will be collected to identify predictors of rescue ventilation. Data will be analyzed to determine which factors are associated with desaturation events requiring intervention.

Why it matters

Potential benefit: If successful, the findings could help clinicians predict and prevent oxygen desaturation, reducing emergency ventilations and improving safety during airway surgeries with THRIVE.

How similar studies have gone: THRIVE has been shown to prolong safe apnea and reduce desaturation in airway procedures, but using patient- and procedure-level predictors to forecast rescue ventilation events is relatively untested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adult patients undergoing elective airway surgery under general anesthesia with Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE)
* Patients who provide written informed consent

Exclusion Criteria:

* Patients who decline to participate in the study

Where it's running

  • Seoul National University Hospital
    Seoul, South Korea
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.