Factors linked to death in Streptococcal anginosus bloodstream infection
Factors Associated With Mortality in Streptococcal Anginosus Bacteremia
University Hospital, Strasbourg, France · NCT07343167
This project looks at medical records of adults hospitalized with Streptococcal anginosus bacteremia to see which factors are linked to a higher risk of death.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Strasbourg, France (other) |
| Locations | 1 site (Strasbourg) |
| Trial ID | NCT07343167 on ClinicalTrials.gov |
What this trial studies
This observational study reviews adults hospitalized between January 1, 2019 and December 31, 2024 at participating centers who had at least one positive blood culture for Streptococcus anginosus, S. constellatus, or S. intermedius. Investigators will extract clinical, microbiological, comorbidity, and treatment data from hospital records and analyze which patient characteristics, infection sources, or management factors are associated with in-hospital mortality. No experimental treatments are given; the work is a retrospective chart-based analysis and excludes patients who refuse participation. The aim is to identify risk factors that could guide earlier recognition and more targeted care for high-risk patients.
Who should consider this trial
Good fit: Adults (18+) hospitalized at a participating center during 2019–2024 with at least one positive blood culture for a Streptococcus anginosus group organism who do not refuse participation are eligible.
Not a fit: People under 18, outpatients, or patients without a confirmed Streptococcal anginosus bloodstream infection are unlikely to benefit directly from this study.
Why it matters
Potential benefit: If successful, results could help clinicians identify high-risk patients sooner and tailor care to reduce deaths from these infections.
How similar studies have performed: Previous observational studies have reported high mortality (~15%) with S. anginosus group bacteremia, but factors driving death remain incompletely defined.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Major subject (≥18 years old) * Hospitalized between January 1, 2019, and December 31, 2024, in one of the participating centers * Having presented during the study period at least one positive blood culture for Streptococcus anginosus, Streptococcus constellatus, or Streptococcus intermedius in a laboratory at a participating center Exclusion Criteria: * Refusal to participate in the study
Where this trial is running
Strasbourg
- Centre de référence des maladies vectorielles à tiques, CNR Borrelia - CHU de Strasbourg - France — Strasbourg, France (RECRUITING)
Study contacts
- Study coordinator: Victor GERBER, MD
- Email: victor.gerber@chru-strasbourg.fr
- Phone: 33 3 68 85 37 97
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Streptococcal Infections, Streptococcal Anginosus Bacteremia, Streptococcal anginosus infections