Facial-expression and biomarker approach to recognize pain in fibromyalgia.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study enrolled 122 participants, 61 with fibromyalgia and 61 without, to compare facial-expression patterns and molecular markers associated with pain. Researchers recorded facial expressions and analyzed them with a convolutional neural network to identify patterns linked to pain intensity. They also collected 1 mL saliva samples to extract DNA, RNA, and plasma proteins measured by ELISA and RT-qPCR, and correlated those findings with self-reported measures like the Visual Analogue Scale and Generalized Pain Index. Statistical agreement and bias were examined using Kappa and Bland-Altman analyses to validate the combined AI and biomarker approach.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The inclusion criteria are patients with no diagnosed cognitive deficit and who are willing to take part in the study.

Exclusion Criteria:

* Exclusion criteria are patients who use medication that can affect anxiety or depression or inability to understand the instructions.

Where it's running

• Outpatient Faculty Medical Sciences
  Belo Horizonte, Minas Gerais, Brazil Recruiting

Study contacts

• Study coordinator: Alessandra H De Souza, PhD
• Email: alessandra.souza@cienciasmedicasmg.edu.br
• Phone: 55-31984205240

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Whole-body Cryotherapy for Fatigue in ME/CFS, Fibromyalgia, Long COVID

  This study tests whether brief, repeated exposure to extreme cold can help reduce fatigue and related symptoms in adults with ME/CFS, fibromyalgia, or Long COVID compared to healthy controls.

  Recruiting Oxford Brookes University · Oxford, Oxon · NCT07874217

• Noninvasive brain stimulation to see if it lowers pain in fibromyalgia

  This study tests whether daily noninvasive brain stimulation can reduce pain and improve quality of life for people with fibromyalgia, using two brain targets and a crossover design.

  Recruiting Carnegie Mellon University · Pittsburgh, Pennsylvania and 1 other locations · NCT07644221

• Home-based high-dose tDCS for fibromyalgia: predicting response and comparing brain targets

  This study tests whether a high-dose home-based tDCS treatment is at least as good as the conventional home-based tDCS for people with fibromyalgia, and whether it could be better, while also checking if baseline EEG can predict who responds.

  Recruiting Ionclinics & Deionic SL · Valencia · NCT07583056

• Dietary strategies to help fibromyalgia in overweight or obese women

  This trial tests whether a very low-calorie ketogenic diet, a Mediterranean diet, or a Mediterranean diet with a probiotic can reduce fibromyalgia symptoms in overweight or obese women.

  Recruiting Universita degli Studi di Genova · Genova, Genova · NCT07517757

• Isokinetic microdose exercise for women with fibromyalgia

  This 8-week program will test whether low-dose isokinetic exercise helps women with fibromyalgia reduce pain, improve strength, and enhance quality of life.

  Recruiting European University Miguel de Cervantes · Valladolid, Valladolid · NCT07483216

• Does hardaliye help fibromyalgia when added to a personalized diet?

  This study tests whether a traditional grape-based drink called hardaliye, used with a personalized diet, can improve symptoms and inflammation in adult women with fibromyalgia.

  Recruiting Hacettepe University · Istanbul, Istanbul · NCT07403929

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.