F-18 PET/CT-Guided Lu-177 Therapy Added to Corticosteroid Injections for Chronic Plantar Fasciitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized pilot trial comparing two intralesional treatment strategies for chronic plantar fasciitis. Participants aged 18–80 with at least six months of heel pain, a baseline pain score of 4 or higher, and focal uptake on F-18 NaF PET/CT are eligible. Forty participants will be enrolled, with 20 in each arm: one group receives F-18 NaF PET/CT-guided Lutetium-177 corticosteroid and local anesthetic injections, the other receives F-18 NaF PET/CT-guided corticosteroid and local anesthetic injections alone. Primary outcomes assess changes in foot pain and function, using the designated regional measures. The study aims to determine if the Lu-177–based addition offers superior pain relief and functional gains compared with corticosteroid injections alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 18-80 years with chronic plantar fasciitis (\>6 months).
2. Failed to conservative therapy.
3. Baseline VAS ≥4.
4. Focal uptake at plantar fascia insertion on F-18 NaF PET/CT.

Exclusion Criteria:

1. Prior radiation therapy to the foot/heel.
2. Active infection at the injection site or systemic infection.
3. Pregnancy or lactation. (Pregnancy test for women of childbearing potential.)
4. Coagulopathy (INR \>1.5 or platelets \<100,000/µL) is not correctable.
5. Uncontrolled diabetes or severe peripheral vascular disease affecting wound healing.
6. Known allergy to agents would be used for local anaesthesia or to any component of the injection.

Where it's running

• Postgraduate Institute of Medical Education and Research, Chandigarh
  Chandigarh, Chandigarh, India Recruiting

Study contacts

• Study coordinator: Rajender Kumar
• Email: drrajender2010@gmail.com
• Phone: +91 9216605341

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.