Eye drops made from a child's own blood serum for dry eyes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study tests autologous serum eye drops (ASEDs) in children with moderate-to-severe dry eye syndrome who have not responded to conventional artificial tears. ASEDs are prepared from a patient's own blood and contain growth factors and proteins that mimic natural tears to promote epithelial healing and reduce inflammation. Participants who meet inclusion and exclusion criteria receive the autologous serum drops and are monitored for clinical signs, symptoms, and safety outcomes over a specified follow-up period. The single-site trial is conducted at The General Authority for Teaching Hospitals and Institutes in Cairo and excludes patients with active ocular infection, recent ocular surgery, systemic immunosuppression, or allergy to blood-derived products.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children aged less than 18 years.
* Both sexes.
* Diagnosed with moderate to severe dry eye syndrome (DES) refractory to artificial tears.

Exclusion Criteria:

* Active ocular infection.
* Recent ocular surgery.
* Systemic immunosuppressive therapy.
* History of allergy to blood-derived products.

Where it's running

• The General Authority for Teaching Hospitals and Institutes
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Hossam A Hassan, MD
• Email: Dr.hossameabdalfataah@gothi.gov.eg
• Phone: 00201026808348

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Intravenous ABBV-319 for adults with SLE or Sjögren's disease

  This trial will test whether two IV doses of ABBV-319 given 21 days apart are safe, reach expected blood levels, and might help adults with SLE or Sjögren's disease.

  Recruiting at 9 sites Phase 1 AbbVie · Avon Park, Florida and 10 other locations · NCT06977724

• Analyzing tear samples to identify eye surface conditions

  This study is testing tear samples from patients with eye surface conditions like dry eye and allergies to see if they can identify unique markers for these issues.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec and 1 other locations · NCT04198740

• TearCare treatment for stable corneal measurements before cataract surgery

  This study tests whether TearCare therapy followed by gland expression helps stabilize the tear film so pre-surgery measurements for cataract planning are more reliable for people with dry eye and meibomian gland dysfunction.

  Recruiting Cleveland Eye Clinic · Largo, Florida and 1 other locations · NCT07928986

• Perioperative Miebo for LASIK-Associated Dry Eye

  This study tests whether Miebo taken four times daily around the time of LASIK can reduce eye dryness in adults with dry eye disease.

  Recruiting at 3 sites Phase 4 Vance Thompson Vision · Bozeman, Montana and 3 other locations · NCT07650708

• Autologous Serum Eye Drops for Severe Dry Eye: Protein Factors and Response

  This study tests whether the protein makeup of a patient’s own serum eye drops explains how well those drops work for severe dry eye.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Saint-Etienne · NCT07632534

• New ocular lubricating eye drop for dry eye relief

  This study tests ABR2, a new eye drop, to see if it is safe and comfortable for short-term relief of dry eye symptoms in adults.

  Recruiting Pleryon Therapeutics (Hangzhou) Limited · Waterloo, Ontario · NCT07593404

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.