Exploring VISTA Levels in Patients with Vascular Cognitive Impairment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the expression levels of the immune checkpoint VISTA in the blood and cerebrospinal fluid of patients with cardiovascular risk factors. It aims to correlate these levels with various risk factors such as hypertension and diabetes, as well as immune-inflammatory factors like IL1 and TNFα. The study includes a follow-up of patients over 3 to 5 years to track changes in VISTA levels and their relationship with cognitive impairment. The research is conducted at the First Hospital of Harbin Medical University.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. The study included 100 subjects, including 50 patients with VCI and 50 normal controls. The diagnosis of VCI was based on the diagnostic criteria for psychiatric disorders in the fifth revised edition of the "Diagnostic and Statistical Manual of Mental Disorders" of the American Psychiatric Association;
2. All relevant examination and cognitive testing work in this study obtained informed consent from the subjects and their families.

Exclusion Criteria:

1\. In line with the exclusion criteria for VCI diagnosis in the "Chinese guidelines for the treatment of vascular cognitive impairment 2019"; complicated with autoimmune diseases, blood diseases, malignant tumors, heart, liver, and kidney dysfunction, infectious diseases, family genetic diseases, recent acute or chronic inflammatory diseases, myocardial infarction, etc.; taking antibiotics, steroids, immunosuppressants before the trial; having a history of cranial trauma or surgery.

Where it's running

• First Affiliated Hospital of Harbin Medical University
  Harbin, Heilongjiang, China Recruiting

Study contacts

• Study coordinator: Dan Liu
• Email: liudan19911214@126.com
• Phone: 15145086350

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Nitrate-rich beetroot juice to improve brain blood-flow control in cognitive decline

  This test gives nitrate-rich beetroot juice or a placebo to people with small vessel cerebrovascular disease or diabetes to see if it improves brain blood-flow regulation and thinking skills.

  Recruiting at 2 sites University of Coimbra · Coimbra and 1 other locations · NCT07329647

• Evaluating antiplatelet therapy for cerebral small vessel diseases

  This study is testing if different blood-thinning medications can help people aged 30 to 79 with small vessel disease in the brain feel better and improve their condition.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT06715007

• Determining the best LDL cholesterol levels for small vessel occlusion stroke prevention

  This study is testing the best cholesterol levels and treatments for people who have had small vessel occlusion strokes to see how they can prevent more strokes.

  Recruiting at 43 sites Seoul National University Hospital · Ansan and 45 other locations · NCT06649240

• Telecoached exercise program to boost brain connectivity after small vessel (lacunar) stroke

  This program will test whether a 24-week, twice-weekly telecoached exercise plan can improve brain connectivity and physical fitness in people aged 60+ who had a lacunar stroke and are currently not very active.

  Recruiting University of L'Aquila · Avezzano, L'Aquila · NCT06525987

• A digital tool for assessing cognitive impairment in stroke survivors

  This study is testing a new digital tool that helps stroke survivors check for thinking and memory problems on their own to improve their care after a stroke.

  Recruiting Imperial College London · London · NCT05885295

• Understanding the prognosis of cerebral small vessel disease

  This study looks at how different types of cerebral small vessel disease affect the health and future outcomes of patients, including issues like bleeding in the brain and memory problems.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT05734378

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.