Exploring the Temporo-masseteric Nerve Block in Healthy Volunteers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to characterize the Temporo-masseteric Nerve Block (TMNB) injection in 20 healthy volunteers. It will assess bite-force distribution and surface electromyographic activity of the temporalis and masseter muscles before and after the TMNB injection. Evaluations will occur at 30 minutes, 2 hours, and 2 weeks post-injection, with participants also providing feedback on their experience. The study seeks to understand the TMNB's effects on muscle activity and its potential for sustained pain relief.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-64 years of age
* All ethnicity
* Male and female sex
* Fluent in written/spoken English
* Never been diagnosed with TMD
* No significant history of orofacial pain
* \<5 headaches/month in the 3 months before enrollment
* No reported use of a nightguard or occlusal splint 'No' to all questions on self-administered questionnaire for TMD screening:
* Pain in jaw or temple on either side of the face in the last 30 days
* Stiffness or pain in jaw upon awakening in the last 30 days
* Any pain increase/reduction in the jaw/temple region during the last 30 days with

  * Chewing hard or tough food
  * Opening mouth or moving jaw forward or to the side
  * Hold teeth together/clenching/grinding/chewing gum
  * Using the jaw during activities such as talking, kissing or yawning

Exclusion Criteria:

* Traumatic injury/ surgery on face or jaw \< 6 months
* current orthodontic treatment
* pregnant or nursing,
* kidney failure or renal dialysis,
* heart disease or heart failure,
* uncontrolled chronic respiratory disease/ hypertension/ diabetes
* history of
* seizures
* hyperthyroidism
* drug or alcohol abuse
* psychiatric disorder/conditions requiring hospitalization
* chemotherapy/radiation

Where it's running

• Rutgers School of Dental Medicine
  Newark, New Jersey, United States Recruiting

Study contacts

• Principal investigator: Gayathri D Subramanian, DMD — Rutgers School of Dental Medicine
• Study coordinator: Gayathri D Subramanian
• Email: subramga@sdm.rutgers.edu
• Phone: 9739723418

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.