Exploring the Skin's Role in Frontotemporal Lobar Degeneration

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the relationship between skin pathology and frontotemporal lobar degeneration (FTLD), a neurodegenerative disorder characterized by behavioral and language decline. Participants diagnosed with various forms of FTLD will undergo skin biopsies and blood sample collection at Nantes University Hospital over a 24-month period. Healthy volunteers will also be included for comparative analysis. The aim is to understand how protein deposits associated with FTLD manifest in the skin, potentially providing insights into the disease's progression.

Why it matters

Who can join: the full rules

Inclusion Criteria (patients):

* Adressed or followed at memory clinic or ALS expert center at Nantes university hospital.
* Aged 50-75 years
* Fulfilling current diagnosis criteria for one of the disorder: vcfFTD, non-Alzheimer PPA (semantic or non fluent), DCB or PSP,ALS
* MMSE ≥ 18
* Membership of social security scheme

Inclusion Criteria (healthy volunteers):

* No history of neurological disease, diabetes, or alteration/damage of peripheral nervous system
* Aged 50-75 years Paired to at least one patient on age (less or more 5 years)
* MOCA ≥ 26
* Membership of social security scheme

Non inclusion Criteria (Patients and healthy volunteers):

* Concomitting conditions affecting the peripheral nervous system such as but not limited to diabetes, renal failure, thyroid disorder, vitamin B12 deficiency, acute and chronic inflammatory diseases HIV, syphilis
* Know allergy to local anesthetic
* Known coagulopathy
* Pregnant women or breastfeeding women
* Person under court protection sous sauvegarde de justice
* Person under guardianship
* Inability to sign an informed consent

Non inclusion criteria (Patients) • Patient with neurological disease other than FTLD

Non inclusion criteria (Healthy volunteers) :

• Evidence of neurological disorder at the inclusion including but not limted to FTLD, Parkinson disease, Alzheimer disease, lewy body dementia, Huntington disease, systemic lupus erythematosus multiple sclerosis; learning disabilities, mental retardation, severe hypoxic brain injuries, brain trauma with permanent cognitive impairments.

Where it's running

• Nantes University Hospital
  Nantes, France Recruiting

Study contacts

• Study coordinator: Claire BOUTOLEAU-BRETONNIERE, MD
• Email: claire.boutoleaubretonnière@chu-nantes.fr
• Phone: 02 40 16 54 22

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.