Exploring the Role of Sirtuins in Atherosclerosis and Aortic Stenosis
Official title: Potential Role of Sirtuins As Epigenetic Biomarkers for the Clinical Management of the Patient with Atherosclerosis or Calcific Aortic Stenosis
Run by Irccs Synlab Sdn · NCT06337227 · Data updated 2026-11-12
This study is testing if certain proteins called Sirtuins can help us understand heart problems like atherosclerosis and aortic stenosis in people, especially those with diabetes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 3 (estimated) |
| Sponsor | Irccs Synlab Sdn Academic / other |
| Locations | 1 site (Naples) |
| Status | Recruiting |
| Started | October 19, 2023 |
| Main results expected | October 2025 |
| Study ends | October 2026 |
| Registry record updated | March 11, 2025 |
| Trial ID | NCT06337227 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 years with atherosclerosis or calcific aortic stenosis, with or without diabetes.
✕Probably not a fit
Patients who cannot provide biological material for the study or refuse to participate will not benefit from this research.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the role of Sirtuins, particularly Sirtuin 6 (SIRT6), as potential epigenetic biomarkers in patients with atherosclerosis and calcific aortic stenosis, including those with diabetes. The research focuses on molecular-based and epigenetic analyses using human vascular smooth muscle cells (VSMC). By examining the lncRNA signature, the study aims to enhance understanding of the mechanisms underlying these cardiovascular conditions.
Why it matters
Potential benefit: If successful, this study could lead to new biomarkers for early detection and treatment strategies for atherosclerosis and calcific aortic stenosis.
How similar studies have gone: While the role of Sirtuins in cardiovascular diseases is being explored, this specific approach focusing on SIRT6 and its epigenetic implications is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with atherosclerosis or calcific aortic stenosis with and without diabetes older than 18 years of either sex; * Patients without atherosclerosis undergoing surgical procedure for endocarditis; * Patients who will have signed informed consent Exclusion Criteria: * Patients for whom biological material cannot be recovered for study purposes; * Patients who refuse to participate in the study
Where it's running
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Irccs Synlab Sdn
Naples, Italy Recruiting
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.