Exploring the role of gut bacteria in postoperative ileus after colorectal surgery
Evaluation of the Role of the Intestinal Microbiota in the Mechanism of Postoperative Ileum After Colorectal Surgery : a Preliminary Study
This study is trying to see if the bacteria in the gut affect the chances of developing a common problem called postoperative ileus after colorectal surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Angers Government |
| Locations | 1 site (Angers) |
| Trial ID | NCT05512741 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between intestinal microbiota and the occurrence of postoperative ileus (POI) following laparoscopic colorectal surgery. By collecting fecal samples from patients, the study aims to identify potential microbial factors that contribute to the development and duration of POI. Understanding these factors could lead to new strategies for reducing the incidence of this common complication, which affects a significant percentage of patients undergoing colorectal surgery.
Who should consider this trial
Good fit: Ideal candidates for this study are patients undergoing laparoscopic colorectal resection with anastomosis and without a diverting stoma.
Not a fit: Patients with conditions that modify the microbiota or those experiencing postoperative complications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to targeted interventions that reduce the occurrence and duration of postoperative ileus, improving recovery times for patients.
How similar studies have performed: While the role of intestinal microbiota in postoperative ileus is not well established, similar studies exploring gut bacteria's impact on other surgical outcomes have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * laparoscopic colorectal resection with anastomosis and without diverting stoma Exclusion Criteria: * risk of modification of the microbiota (terminal enterostomy, chronic inflammatory bowel disease, oesophageal or gastric surgery, vagal nerves lesion, beta lactamin allergy, bowel cleansing) * postoperative complication
Where this trial is running
Angers
- Angers University Hospital, visceral and endocrine surgery department — Angers, France (Recruiting)
Study contacts
- Study coordinator: Aurélien Venara, MD, PhD
- Email: auvenara@chu-angers.fr
- Phone: 0033241353618
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.