Exploring the role of FKBP5 in stroke recovery
Clinical Implications of FKBP5 in Post-stroke Neural Plasticity and Neuromodulation Effects
This study is testing how a specific gene related to stress affects recovery after a stroke and whether a brain stimulation technique can help improve rehabilitation based on individual differences.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 500 (estimated) |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Sponsor | Taipei Veterans General Hospital, Taiwan Government |
| Locations | 1 site (Taipei City) |
| Trial ID | NCT05198037 on ClinicalTrials.gov |
What this trial studies
This study investigates how the FKBP5 gene and its related pathways influence recovery outcomes after a stroke. It focuses on the relationship between FKBP5 gene polymorphisms, blood levels of FKBP51, and their effects on brain plasticity and excitability. The study employs bihemispheric transcranial direct current stimulation (tDCS) to assess its impact on stroke rehabilitation and aims to identify individualized approaches for early recovery based on genetic and physiological factors.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 20-80 who have experienced a unilateral ischemic or hemorrhagic stroke.
Not a fit: Patients with a high level of upper extremity function, major psychiatric or neurologic diseases, or global aphasia may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to personalized rehabilitation strategies that enhance recovery outcomes for stroke patients.
How similar studies have performed: While the specific approach of linking FKBP5 to stroke recovery is novel, related studies on stress and brain plasticity have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Unilateral ischemic or hemorrhagic stroke * Aged 20-80 years old Exclusion Criteria: * FMA-UE is over 49 points * Major psychiatric diseases * Major neurologic diseases * Global aphasia
Where this trial is running
Taipei City
- Taipei Veterans General Hospital — Taipei City, Taiwan (Recruiting)
Study contacts
- Study coordinator: I-Hui Lee, MD, PhD
- Email: ihlee@vghtpe.gov.tw
- Phone: + 886-2-28712121
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.