Exploring the Role of Antibiotics in Women with Recurrent Miscarriage and Chronic Endometritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to estimate the incidence of chronic endometritis (CE) in women experiencing unexplained recurrent miscarriage. Eligible participants will undergo endometrial sampling during their menstrual cycle to evaluate the presence of microorganisms associated with CE. The study will also investigate the therapeutic benefits of antibiotics, with treatment tailored based on the identified infectious agents or empirical protocols. Follow-up endometrial biopsies will assess the effectiveness of the antibiotic treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women with a history of 2 or more consecutive miscarriages before 24 weeks of gestation
* Women aged 20-45 years old

Exclusion Criteria:

* Uncorrected uterine anomalies, such as the septate or bicornuate uterus, fibroids (submucous/intramural)
* Untreated hydrosalpinx
* Antiphospholipid syndrome
* Known clinical autoimmune disease
* Undergoing immunotherapy
* Abnormal thyroid function
* Abnormal karyotyping of couples
* Known immunodeficiency pathologies such as diabetes or HIV
* Currently taking other antibiotics or other trial medications or TCM;
* Currently or previously involved in other clinical trials with medication intake;
* Those with active pelvic inflammatory disease or suspicion of infection etc.

Where it's running

• The Chinese University of Hong Kong
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Jacqueline Pui Wah Chung, MBBS — Chinese University of Hong Kong
• Study coordinator: Stacey Wong, BSc
• Email: staceywong@cuhk.edu.hk
• Phone: 35051764

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.