Clinical trial Recruiting at 1 site Observational Ages 18 and up

Exploring the nasal microbiome's role in diseases like chronic rhinosinusitis and COVID-19

Official title: The Importance of the Nasal Microbiome in Transmission and Disease

Run by University of Aarhus · NCT05061329 · Data updated 2026-11-12

This study looks at the bacteria in the nose of healthy people and those with smell problems from COVID-19 or chronic sinus issues to see how it might affect their health and treatment options.

More COVID-19 trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment619 (estimated)
SponsorUniversity of Aarhus
Academic / other
Drugs / interventionsdupilumab, mepolizumab
Locations1 site (Holstebro, Central Jutland)
StatusRecruiting
StartedDecember 21, 2020
Main results expectedSeptember 29, 2026
Study endsDecember 31, 2026
Registry record updatedDecember 7, 2023
Trial IDNCT05061329 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adults over 18 with chronic rhinosinusitis, olfactory dysfunction, or those recovering from COVID-19.

Probably not a fit

Patients with active anticoagulation treatment, autoimmune diseases, or those who have taken antibiotics or immunomodulating drugs in the last three months may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the nasal microbiome across different patient groups, including healthy individuals and those with olfactory dysfunction related to COVID-19 and chronic rhinosinusitis. It employs case-control and longitudinal cohort designs, collecting microbiome samples from the nasal cavity and oral pharynx for analysis using next-generation sequencing. The study aims to understand how the nasal microbiome differs among these groups and its potential implications for treatment and diagnosis.

Why it matters

Potential benefit: If successful, this study could enhance understanding of the nasal microbiome's role in olfactory dysfunction and lead to improved treatment strategies for chronic rhinosinusitis and COVID-19-related symptoms.

How similar studies have gone: While the study's approach is novel in its specific focus on the nasal microbiome in these conditions, similar studies have shown promising results in understanding microbiome impacts on health.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Exclusion Criteria:

* Does not wish to participate in study

Where it's running

  • Ear, Nose and Throat Department, HEV
    Holstebro, Central Jutland, Denmark
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.