Exploring the nasal microbiome's role in diseases like chronic rhinosinusitis and COVID-19
The Importance of the Nasal Microbiome in Transmission and Disease
This study looks at the bacteria in the nose of healthy people and those with smell problems from COVID-19 or chronic sinus issues to see how it might affect their health and treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 619 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Aarhus Academic / other |
| Drugs / interventions | dupilumab, mepolizumab |
| Locations | 1 site (Holstebro, Central Jutland) |
| Trial ID | NCT05061329 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the nasal microbiome across different patient groups, including healthy individuals and those with olfactory dysfunction related to COVID-19 and chronic rhinosinusitis. It employs case-control and longitudinal cohort designs, collecting microbiome samples from the nasal cavity and oral pharynx for analysis using next-generation sequencing. The study aims to understand how the nasal microbiome differs among these groups and its potential implications for treatment and diagnosis.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 with chronic rhinosinusitis, olfactory dysfunction, or those recovering from COVID-19.
Not a fit: Patients with active anticoagulation treatment, autoimmune diseases, or those who have taken antibiotics or immunomodulating drugs in the last three months may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the nasal microbiome's role in olfactory dysfunction and lead to improved treatment strategies for chronic rhinosinusitis and COVID-19-related symptoms.
How similar studies have performed: While the study's approach is novel in its specific focus on the nasal microbiome in these conditions, similar studies have shown promising results in understanding microbiome impacts on health.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Exclusion Criteria: * Does not wish to participate in study
Where this trial is running
Holstebro, Central Jutland
- Ear, Nose and Throat Department, HEV — Holstebro, Central Jutland, Denmark (Recruiting)
Study contacts
- Principal investigator: Laura Marie Aalkjær Danielsen — student
- Study coordinator: Laura Marie Aalkjær Danielsen
- Email: lauraaalkjaer@hotmail.com
- Phone: +4542714748
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.