Exploring the nasal microbiome's role in diseases like chronic rhinosinusitis and COVID-19
Official title: The Importance of the Nasal Microbiome in Transmission and Disease
Run by University of Aarhus · NCT05061329 · Data updated 2026-11-12
This study looks at the bacteria in the nose of healthy people and those with smell problems from COVID-19 or chronic sinus issues to see how it might affect their health and treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 619 (estimated) |
| Sponsor | University of Aarhus Academic / other |
| Drugs / interventions | dupilumab, mepolizumab |
| Locations | 1 site (Holstebro, Central Jutland) |
| Status | Recruiting |
| Started | December 21, 2020 |
| Main results expected | September 29, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | December 7, 2023 |
| Trial ID | NCT05061329 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 with chronic rhinosinusitis, olfactory dysfunction, or those recovering from COVID-19.
✕Probably not a fit
Patients with active anticoagulation treatment, autoimmune diseases, or those who have taken antibiotics or immunomodulating drugs in the last three months may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the nasal microbiome across different patient groups, including healthy individuals and those with olfactory dysfunction related to COVID-19 and chronic rhinosinusitis. It employs case-control and longitudinal cohort designs, collecting microbiome samples from the nasal cavity and oral pharynx for analysis using next-generation sequencing. The study aims to understand how the nasal microbiome differs among these groups and its potential implications for treatment and diagnosis.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the nasal microbiome's role in olfactory dysfunction and lead to improved treatment strategies for chronic rhinosinusitis and COVID-19-related symptoms.
How similar studies have gone: While the study's approach is novel in its specific focus on the nasal microbiome in these conditions, similar studies have shown promising results in understanding microbiome impacts on health.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Exclusion Criteria: * Does not wish to participate in study
Where it's running
-
Ear, Nose and Throat Department, HEV
Holstebro, Central Jutland, Denmark Recruiting
Study contacts
- Principal investigator: Laura Marie Aalkjær Danielsen — student
- Study coordinator: Laura Marie Aalkjær Danielsen
- Email: lauraaalkjaer@hotmail.com
- Phone: +4542714748
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.