Exploring the links between cognitive processes and brain lesions through a verbal fluency task

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how executive and linguistic processes relate to verbal fluency deficits in patients with cognitive neurodegenerative diseases and stroke. Participants will undergo a verbal fluency test, which is sensitive to brain diseases, to identify the origins of their deficits. By analyzing the results, researchers aim to clarify the lesion determinants associated with these cognitive challenges. The study utilizes advanced imaging techniques to better understand the brain structures involved in verbal fluency.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* For Cognitive cortical neurodegenerative diseases PATIENTS
* informed consentPatients between 40 and 85 years old,
* French native language,
* Social Security affiliation,
* Can read, write and count (up to 36) and knows the alphabet
* Assessed in Amiens University Memory Clinic for:
* Mild severity impairment (MMSE\> 19) or major severity impairment related to:
* AD according to Albert criteria and McKhann criteria
* DCL according to McKeith criteria
* FTLD according to Rascovsky criteria
* CBD according to Armstrong's criteria
* PSP according to Höglinger criteria
* For Stroke PATIENTS
* informed consent
* Patients between 40 and 85 years old,
* French native language,
* Social Security affiliation,
* Can read, write and count (up to 36) and knows the alphabet
* Having suffered a stroke, hospitalized in neurology, visualized by imaging

Exclusion Criteria:

* Mental retardation or guardianship
* Other current or past brain condition affecting cognition, including:
* Severe head trauma
* Epilepsy prior to stroke still requiring previous treatment
* Parkinson disease, multiple sclerosis
* Brain tumor or brain radiation therapy
* Current or past schizophrenia or psychosis
* Active or past psychiatric impairments requiring a stay\> 2 days in a specialized environment
* Contra indication to MRI
* Comorbidity with life expectancy \<1 year
* Comorbidity affecting cognition in particular:
* Alcohol (\> 3 glasses / day) or history of alcohol withdrawal syndrome
* Opiate or cocaine addiction or opiate withdrawal syndrome
* Renal failure (dialysis or creatinine clearance \<30)
* Hepatic failure (spontaneous INR\> 1.5 or PT \<60%)
* Respiratory failure requiring oxygen therapy
* Heart failure (orthopnea\> 2 pillows)
* Persistent vigilance disorder (NIHSS1a score ≤1)
* Cancer with paraneoplastic syndrome
* Treatment with gold salts, D Penicillamine or other treatment with cognitive effect
* Patient under guardianship or curators or private under public law
* Pregnant and / or lactating woman

Where it's running

• CHU Amiens
  Amiens, France Recruiting

Study contacts

• Study coordinator: Martine ROUSSEL, PhD
• Email: roussel.martine@chu-amiens.fr
• Phone: 0322668240

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.