Exploring the links between cognitive decline and sleep patterns in aging and Alzheimer's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how cognitive deficits associated with aging and Alzheimer's disease relate to slow wave activity measured through EEG during both sleep and wakefulness. The researchers aim to identify slow waves as a potential biomarker for sleep disturbances and daytime vigilance issues that affect memory processes. By examining these relationships, the study seeks to understand how alterations in sleep and attention impact memory encoding, consolidation, and retrieval in older adults. Participants will undergo video polysomnography and attention tasks to gather data on their cognitive and sleep patterns.

Why it matters

Who can join: the full rules

* Common Inclusion Criteria for All Three Groups:

Male or female Signed informed consent Affiliated with a social security system Native French speakers Completed at least 7 years of schooling (minimum 9th grade level)

Specific Inclusion Criteria for Each Group:

Patients:

Age: 60 to 85 years Prodromal stage of Alzheimer's disease diagnosed according to international diagnostic criteria, characterized by a clinical phenotype of progressive amnesic syndrome of the hippocampal type, associated with biological markers of Alzheimer's disease 1) from lumbar puncture (Aβ \< 600 pg/mL and ptau \> 60 pg/mL)or 2) amyloid PET (positron emission tomography), or 3) with positive plasma Alzheimer's biomarkers

Cognitively Healthy Seniors:

Age: 60 to 85 years Age and sex matched with the Patients group "Cognitively healthy" status defined by a score of ≥ 26 on the MMSE (Mini-Mental State Examination), a score of ≥ 16 on the BREF (Batterie Rapide d'Efficience Frontale), and a score of ≥ 8 on the 5-word test

Young Adults:

Age: 18 to 35 years Sex matched with the Patients group "Cognitively healthy" status defined by a score of ≥ 26 on the MMSE (Mini-Mental State Examination), a score of ≥ 16 on the BREF (Batterie Rapide d'Efficience Frontale), and a score of ≥ 8 on the 5-word test

Where it's running

• Maladies du Sommeil
  Paris, France Recruiting

Study contacts

• Principal investigator: Marc Teichmann, MD — assisitance publique Hôpitaux de paris
• Study coordinator: Marc Teichmann, MD
• Email: marc.teichmann@aphp.fr
• Phone: 01 42 16 75 34

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.