Exploring the link between ultra-processed foods and eosinophilic esophagitis
The Potential Role of Compounds Derived From Ultra-processed Foods in Pathogenesis of Eosinophilic Esophagitis
Federico II University · NCT06093204
This study is trying to see if eating ultra-processed foods is linked to eosinophilic esophagitis symptoms in kids and teens aged 3 to 18.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 3 Years to 65 Years |
| Sex | All |
| Sponsor | Federico II University (other) |
| Locations | 2 sites (Naples and 1 other locations) |
| Trial ID | NCT06093204 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the potential role of compounds derived from ultra-processed foods in the development of eosinophilic esophagitis (EoE), a chronic inflammatory condition of the esophagus. It aims to evaluate dietary habits and their correlation with EoE symptoms in children and adolescents aged 3 to 18 years. Participants will include diagnosed EoE patients and age- and sex-matched healthy controls, with a focus on understanding how diet may influence the pathogenesis of this condition. The study will involve dietary evaluations to gather relevant data.
Who should consider this trial
Good fit: Ideal candidates for this study are children and adolescents aged 3 to 18 years with a confirmed diagnosis of eosinophilic esophagitis.
Not a fit: Patients with other chronic diseases or those outside the specified age range may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to dietary recommendations that help manage or prevent eosinophilic esophagitis in affected individuals.
How similar studies have performed: While the specific approach of linking ultra-processed foods to EoE is novel, similar dietary studies have shown promise in understanding other inflammatory conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * both sexes * age between 3-65 years * sure diagnosis of eosinophilic esophagitis * age- and sex-matched healthy controls * parents/tutor written informed consent. Exclusion Criteria: * lack of written informed consent; * non-Caucasian ethnicity * age at enrollment \< 3 or \>65 years * simultaneous presence of other chronic diseases: eosinophilic gastroenteritis, eosinophilic colitis, achalasia, GERD, hypereosinophilia syndrome, IBD, fungal or viral infections, connective tissue disorders, autoimmune diseases, vasculitis, bullous dermatosis with oesophageal involvement (pemphigus), drug hypersensitivity reactions, drug-induced oesophagitis, graft vs host disease, monogenic disorders (Marfan syndrome type 2, HIES, PTEN). * presence of tattoos, scars, moles or particular lesions on both forearms
Where this trial is running
Naples and 1 other locations
- Department of Traslational Medical Science - University of Naples Federico II — Naples, Italy (RECRUITING)
- Department of Traslational Medical Science - University of Naples Federico II — Naples, Italy (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Esophagitis, Eosinophilic