Exploring the link between microbial infection and lumbar degenerative diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the potential correlation between microbial infections and lumbar degenerative diseases using advanced high-throughput gene sequencing technology. By analyzing both blood samples and intervertebral disc tissue from patients, the researchers aim to identify specific microorganisms that may contribute to the development and progression of these conditions. The study seeks to enhance understanding of the pathogenesis of lumbar degenerative diseases and provide new insights for prevention and treatment strategies. The research is funded with a budget of 50,000 RMB.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients in the experimental group, aged 18 to 85 years old, have symptoms and imaging data that support the diagnosis of lumbar degenerative diseases (including lumbar disc herniation, lumbar spinal stenosis, and lumbar spondylolisthesis).
* Patients who undergo strict conservative treatment for 3 months before surgery have no significant improvement in symptoms; The control group of patients had no significant lumbar disc degeneration evaluated by imaging, but needed surgical decompression and fusion intervention due to trauma causing lumbar fractures, lumbar tumors, scoliosis.
* The disc organizer can be obtained during surgery.

Exclusion Criteria:

* Lumbar degenerative diseases combined with infectious diseases.
* Lumbar degenerative diseases combined with mental diseases.
* Lumbar degenerative diseases combined with metal allergy.

Where it's running

• Hao-Xuan Zhang
  Jinan, Shandong, China Recruiting

Study contacts

• Study coordinator: Hao-Xuan Zhang, Ph.D/MD
• Email: hoho0605@126.com
• Phone: +8615275105665

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.