Exploring the link between microbial infection and lumbar degenerative diseases
The First Affiliated Hospital of Shandong First Medical University
This study is trying to see if certain infections caused by tiny germs are linked to back problems in the lower spine to help find better ways to prevent and treat these issues.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Qianfoshan Hospital Academic / other |
| Locations | 1 site (Jinan, Shandong) |
| Trial ID | NCT06075979 on ClinicalTrials.gov |
What this trial studies
This study investigates the potential correlation between microbial infections and lumbar degenerative diseases using advanced high-throughput gene sequencing technology. By analyzing both blood samples and intervertebral disc tissue from patients, the researchers aim to identify specific microorganisms that may contribute to the development and progression of these conditions. The study seeks to enhance understanding of the pathogenesis of lumbar degenerative diseases and provide new insights for prevention and treatment strategies. The research is funded with a budget of 50,000 RMB.
Who should consider this trial
Good fit: Ideal candidates include patients aged 18 to 85 with diagnosed lumbar degenerative diseases who have not improved after conservative treatment.
Not a fit: Patients with lumbar degenerative diseases that are also combined with infectious or mental diseases, or those with metal allergies may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new prevention and treatment strategies for patients suffering from lumbar degenerative diseases.
How similar studies have performed: While the approach of using high-throughput gene sequencing in this context is innovative, similar studies exploring microbial influences on other degenerative diseases have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients in the experimental group, aged 18 to 85 years old, have symptoms and imaging data that support the diagnosis of lumbar degenerative diseases (including lumbar disc herniation, lumbar spinal stenosis, and lumbar spondylolisthesis). * Patients who undergo strict conservative treatment for 3 months before surgery have no significant improvement in symptoms; The control group of patients had no significant lumbar disc degeneration evaluated by imaging, but needed surgical decompression and fusion intervention due to trauma causing lumbar fractures, lumbar tumors, scoliosis. * The disc organizer can be obtained during surgery. Exclusion Criteria: * Lumbar degenerative diseases combined with infectious diseases. * Lumbar degenerative diseases combined with mental diseases. * Lumbar degenerative diseases combined with metal allergy.
Where this trial is running
Jinan, Shandong
- Hao-Xuan Zhang — Jinan, Shandong, China (Recruiting)
Study contacts
- Study coordinator: Hao-Xuan Zhang, Ph.D/MD
- Email: hoho0605@126.com
- Phone: +8615275105665
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.