Exploring the link between memory and social interactions in Alzheimer's and semantic dementia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates how social interactions can serve as a beneficial context for learning in patients with Alzheimer's disease and semantic dementia. It aims to evaluate the effectiveness of social interactions in enhancing memory and cognitive function among individuals diagnosed with these conditions. Participants will include patients with Alzheimer's disease, semantic variant primary progressive aphasia, and healthy controls, all aged between 50 and 85 years. The study will also involve partners who have maintained regular social interactions with the patients, providing a comprehensive view of the social dynamics at play.

Why it matters

Who can join: the full rules

Inclusion criteria:

* AD group: Age between 50 and 85 years, Diagnosis of probable Alzheimer's disease dementia with amnestic presentation and documented decline following the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.
* SPPA group: Age between 50 and 85 years, Diagnosis of the semantic variant of primary progressive aphasia following the classification of primary progressive aphasia and its variants.
* HC group: Age between 50 and 85 years, Matched in age and sociocultural status with one of the AD or SPPA patients, No cognitive complain, No recent reduction in social or cognitive activities, No contraindication to MRI examination.
* Partners: Age over 18 years of age , No cognitive complaints, Social interactions of at least two hours per week for at least 5 years with one of the individuals of the other three groups.

Exclusion criteria (for all groups):

* Deprivation of liberty by judicial or administrative decision
* Not being a member of a social security system
* Concurrent participation in a therapeutic drug trial
* Uncorrected visual and/or auditory disorders that are sufficiently significant to interfere with the protocol
* History of neurological disorders (stroke, epilepsy, head trauma with loss of consciousness for more than one hour)
* History of chronic alcoholism or drug abuse
* History within the last 10 years of a clinically significant major psychiatric disorder
* Cancer within the past 5 years, except for squamous cell carcinoma
* Use of medications that may affect cognitive and/or brain function. Given the number of molecules involved and the dosages, the principal investigator will judge on a case-by-case basis whether regular use of certain medications will interfere with the study

Where it's running

• Caen University Hospital
  Caen, France Recruiting

Study contacts

• Study coordinator: Olivier MARTINAUD, MD, PhD
• Email: martinaud-o@chu-caen.fr
• Phone: 33 2 31 06 46 17

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.