Exploring the link between major depression and gum disease
Relationship Between Major Depression and Periodontal Diseases: Analytical Cross-sectional Study
This study looks at whether people with major depression have more gum disease than those without depression to see how oral health might affect mental health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 122 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universidad Complutense de Madrid Academic / other |
| Locations | 2 sites (Madrid and 1 other locations) |
| Trial ID | NCT05950009 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the relationship between major depressive disorder and periodontal diseases, specifically periodontitis. It will involve a cross-sectional analysis comparing two groups: individuals with moderate to severe major depression and a control group without mental health issues. The study will assess the prevalence of periodontal diseases in both groups and explore associations with oral and gut microbiomes, inflammatory markers, and intestinal barrier integrity. The goal is to deepen the understanding of how periodontal health may influence mental health outcomes.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with moderate to severe major depression or those without any mental health pathologies.
Not a fit: Patients with diabetes, chronic conditions, or other significant mental health disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the interplay between mental health and oral health, potentially leading to improved treatment strategies for patients with major depression.
How similar studies have performed: While there is existing epidemiological evidence suggesting a link between depression and periodontal disease, this specific approach is novel and has not been extensively tested in human populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age greater or equal to 18 years. * For the case group (MD patients), subjects with moderate or severe major depression, without severe suicide ideation, as characterized by the Patient Health Questionnaire (PHQ)-9 index (values of 9 or greater) and by the Structured Clinical Interview for DSM-5 - (SCID) will be selected. * For the control group, subjects without mental health pathologies identified by SCID, who present an PHQ-9 index of 5 or below will be included as controls. Exclusion Criteria: * Pregnant or breastfeeding women. * Diabetes mellitus. * Chronic conditions: HIV infection, chronic intake of NSAIDs. * Comorbidity with other mental disorders: eating disorders, borderline personality disorders, bipolar disorders, schizophrenia and related disorders, and/or any mental serious disease other than major depression. * Severe suicide ideation. * Patients who had received periodontal treatment for periodontitis in the last year. * Presence of necrotizing periodontal diseases. * Presence of less than three teeth per quadrant. * Antibiotic use in the last 6 months prior to the study.
Where this trial is running
Madrid and 1 other locations
- Faculty of Dentistry, University Complutense of Madrid (UCM) — Madrid, Spain (Recruiting)
- Instituto de Psiquiatría y Salud Mental, Hospital Clínico San Carlos — Madrid, Spain (Recruiting)
Study contacts
- Study coordinator: Elena Figuero Ruiz, Prof.
- Email: elfiguer@ucm.es
- Phone: 0034913942186
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.