Exploring the link between diet and chronic subdural hematoma

Association Between Dietary Factors and Chronic Subdural Hematoma: a Multicenter Case-control Study

This study looks at how different diets might affect the development of chronic subdural hematoma in older adults by comparing their eating habits to those of healthy people.

Quick facts

• Study type: Observational
• Enrollment: 420 (estimated)
• Ages: 18 Years to 90 Years
• Sex: All
• Sponsor: Beijing Tiantan Hospital (other)
• Locations: 4 sites (Huangshan, Anhui and 3 other locations)
• Trial ID: NCT05599217 on ClinicalTrials.gov

What this trial studies

This observational study aims to investigate the relationship between dietary factors and chronic subdural hematoma (CSDH) by comparing patients with CSDH to healthy controls. It will utilize dietary and nutritional questionnaires, neurological assessments, and blood tests to evaluate the impact of nutrition on inflammation and CSDH development. The study seeks to clarify the role of diet in the pathogenesis and prevention of CSDH, particularly in the elderly population who are at higher risk of malnutrition. By identifying dietary influences, the research could lead to improved management strategies for CSDH.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 to 90 with clinical symptoms of chronic subdural hematoma verified by imaging.

Not a fit: Patients with previous intracranial surgeries or severe comorbidities may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide insights into dietary modifications that may help prevent or manage chronic subdural hematoma.

How similar studies have performed: While the association between diet and inflammatory conditions has been explored, this specific investigation into dietary factors and chronic subdural hematoma is novel.

Eligibility criteria

Case group (CSDH group)

Inclusion Criteria:

* Patients (18 years to 90 years) presenting with clinical symptoms and neurological deficits of CSDH.
* CSDH verified on cranial computed tomography or magnetic resonance imaging.
* Written informed consent from patients or their next of kin according to the patient's cognitive status.

Control group (Healthy group)

Inclusion Criteria:

* non-CSDH patients (18 years to 90 years) with matched age and gender.
* Written informed consent from patients or their next of kin according to the patient's cognitive status.

Exclusion Criteria for both case and control group:

* Previous intracranial surgery for any neurological disorders but chronic subdural hematoma before.
* CSDH turned from acute subdural hematoma.
* Existing malignant tumors, poor medication condition or severe comorbidity.
* Difficulty in feeding requiring long-term enteral or parenteral nutrition support.
* Dietary and nutritional survey is estimated to be completed difficultly.
* Reproductive-age women without verified negative pregnancy testing.
* Participating in other research.

Where this trial is running

Huangshan, Anhui and 3 other locations

• Huangshan City People's Hospital — Huangshan, Anhui, China (RECRUITING)
• First People's Hospital of Lianyungang — Lianyungang, Jiangsu, China (RECRUITING)
• People's Hospital of Ningxia Hui Autonomous Region — Yinchuan, Ningxia, China (RECRUITING)
• Beijing Tiantan Hospital, Capital Medical University — Beijing, China (RECRUITING)

Study contacts

• Principal investigator: Weiming Liu, M.D. — Beijing Tiantan Hospital
• Study coordinator: Liang Wu, M.D.

Conditions: Chronic Subdural Hematoma, Chronic subdural hematoma, Dietary inflammatory index, Food frequency questionnaire, Modified frailty index