Exploring the link between deep medullary veins and cognitive issues in small vessel disease

Correlation Between Deep Medullary Veins and Cognitive Dysfunction in Cerebral Small Vessel Disease

This study is trying to see if changes in certain brain veins are linked to thinking problems in people with small vessel disease.

Quick facts

• Study type: Observational
• Enrollment: 200 (estimated)
• Ages: 50 Years to 85 Years
• Sex: All
• Sponsor: Zigong No.1 Peoples Hospital (Academic / other)
• Locations: 1 site (Zigong, Sichuan)
• Trial ID: NCT05715710 on ClinicalTrials.gov

What this trial studies

This observational study investigates the relationship between cognitive impairment and imaging characteristics in patients with Cerebral Small Vessel Disease (CSVD). It employs comprehensive neuropsychological assessments and advanced imaging techniques, specifically 3.0T MRI SWI sequences, to measure deep medullary veins (DMVs) and compare various demographic and hematological factors. The goal is to identify whether DMVs can serve as an independent risk factor for cognitive dysfunction and to develop a predictive model for cognitive impairment in CSVD patients.

Who should consider this trial

Good fit: Ideal candidates are individuals aged 50 to 85 diagnosed with Cerebral Small Vessel Disease according to established criteria.

Not a fit: Patients with cognitive impairment due to large vessel disease or other significant neurological conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved early detection and intervention strategies for cognitive impairment in patients with CSVD.

How similar studies have performed: While the specific approach of correlating DMVs with cognitive dysfunction in CSVD is relatively novel, similar studies have explored cognitive impairment in vascular diseases with varying degrees of success.

Eligibility criteria

1. Inclusion Criteria

   1. Age 50 \~ 85 years old.
   2. The diagnostic criteria of CSVD patients with cerebral small vessel diseases should be in accordance with the 2015 Chinese Consensus on the diagnosis and treatment of cerebral small vessel Diseases formulated and recommended by the Cerebrovascular Division of Chinese Society of Neurology, Chinese Medical Association. MRI examination revealed the presence of one or more of the major imaging features of CSVD as proposed by the 2013 International Standards Reporting Group on Neuroimaging of Vascular Changes.
   3. No large vessel stenosis (stenosis rate \> 50%) was found after head and neck vascular examination (CTA, MRA, DSA or TCD combined with carotid ultrasound).
   4. The vital signs are stable and can cooperate with the examination.
   5. Informed consent signed by the patient or legal representative.
2. Exclusion Criteria:

   1. Cerebral infarction or cerebral hemorrhage caused by large vascular disease; And CTA/MRA of the head and neck showed great vessel stenosis (stenosis rate \> 50%).
   2. Patients with secondary white matter lesions caused by poisoning, inflammation, tumor and other pathological changes.
   3. Cognitive impairment and gait impairment caused by other causes (such as Alzheimer's disease, Parkinson's disease, depression, etc.
   4. Patients with contraindications of magnetic resonance examination.
   5. Illiterate or unable to cooperate with cognitive assessment due to severe hearing and visual impairment.

Where this trial is running

Zigong, Sichuan

• Zigong First People's Hospital — Zigong, Sichuan, China (Recruiting)

Study contacts

• Principal investigator: ya x Xu — Zigong No.1 People's Hospital
• Study coordinator: ya x Xu

Conditions Cerebral Small Vessel Disease; deep medullary veins; csvd; cerebral small vessel disease