Exploring the link between deep medullary veins and cognitive issues in small vessel disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between cognitive impairment and imaging characteristics in patients with Cerebral Small Vessel Disease (CSVD). It employs comprehensive neuropsychological assessments and advanced imaging techniques, specifically 3.0T MRI SWI sequences, to measure deep medullary veins (DMVs) and compare various demographic and hematological factors. The goal is to identify whether DMVs can serve as an independent risk factor for cognitive dysfunction and to develop a predictive model for cognitive impairment in CSVD patients.

Why it matters

Who can join: the full rules

1. Inclusion Criteria

   1. Age 50 \~ 85 years old.
   2. The diagnostic criteria of CSVD patients with cerebral small vessel diseases should be in accordance with the 2015 Chinese Consensus on the diagnosis and treatment of cerebral small vessel Diseases formulated and recommended by the Cerebrovascular Division of Chinese Society of Neurology, Chinese Medical Association. MRI examination revealed the presence of one or more of the major imaging features of CSVD as proposed by the 2013 International Standards Reporting Group on Neuroimaging of Vascular Changes.
   3. No large vessel stenosis (stenosis rate \> 50%) was found after head and neck vascular examination (CTA, MRA, DSA or TCD combined with carotid ultrasound).
   4. The vital signs are stable and can cooperate with the examination.
   5. Informed consent signed by the patient or legal representative.
2. Exclusion Criteria:

   1. Cerebral infarction or cerebral hemorrhage caused by large vascular disease; And CTA/MRA of the head and neck showed great vessel stenosis (stenosis rate \> 50%).
   2. Patients with secondary white matter lesions caused by poisoning, inflammation, tumor and other pathological changes.
   3. Cognitive impairment and gait impairment caused by other causes (such as Alzheimer's disease, Parkinson's disease, depression, etc.
   4. Patients with contraindications of magnetic resonance examination.
   5. Illiterate or unable to cooperate with cognitive assessment due to severe hearing and visual impairment.

Where it's running

• Zigong First People's Hospital
  Zigong, Sichuan, China Recruiting

Study contacts

• Principal investigator: ya x Xu — Zigong No.1 People's Hospital
• Study coordinator: ya x Xu
• Email: 502687651@qq.com
• Phone: 15983171312

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Cerebral Small Vessel Disease Progression by Stroke Type

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.