Exploring the link between blood pressure variability and blood vessel function in patients with obstructive sleep apnea
Relationship Between Vascular Endothelial Dysfunction and Beat-to-beat Blood Pressure Variability in Patients With Obstructive Sleep Apnea Syndrome
This study looks at how changes in blood pressure might affect blood vessel health in people with obstructive sleep apnea to better understand their heart risks.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Huai'an No.1 People's Hospital Academic / other |
| Locations | 1 site (Huai'an, Jiangsu) |
| Trial ID | NCT05548569 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how vascular endothelial dysfunction relates to beat-to-beat blood pressure variability in patients suffering from obstructive sleep apnea (OSA). It focuses on the physiological mechanisms affected by intermittent hypoxia and systemic inflammation associated with OSA, which may lead to cardiovascular issues. The study aims to identify differences in blood pressure responses during hypoxic episodes among patients with varying endothelial function. By analyzing these relationships, the research seeks to enhance understanding of cardiovascular risks in OSA patients.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with moderate to severe obstructive sleep apnea and hypertension.
Not a fit: Patients with significant comorbidities such as malignant tumors, severe heart disease, or diabetes may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for cardiovascular risks in patients with obstructive sleep apnea.
How similar studies have performed: While the specific relationship being studied may be novel, previous research has indicated that endothelial dysfunction and blood pressure variability are important factors in cardiovascular health, suggesting potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. ≥18 years old; 2. Moderate to severe OSA(AHI≥15 times/hour); 3. Hypertension (systolic blood pressure ≥140mmHg and/or diastolic blood pressure ≥90mmHg); Exclusion Criteria: 1. Malignant tumor, severe arrhythmia and heart disease, moderate and severe renal dysfunction, peripheral vascular disease, diabetes 2. Systolic blood pressure ≤140mmHg and diastolic blood pressure ≤90mmHg 3. Vigorous exercise 24 hours before the experiment; 4. Vasoactive drugs (ACEI, ARB, CCB, β blockers, nitrates) were used 48 hours before the experiment; 5. Smoking, drinking and consuming caffeinated beverages 12 hours before the experiment
Where this trial is running
Huai'an, Jiangsu
- Jing Xu — Huai'an, Jiangsu, China (Recruiting)
Study contacts
- Study coordinator: Jing Xu, doctor
- Email: xj680390@126.com
- Phone: +8618360942922
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.