Exploring the immune profile of chronic hand eczema

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the immune landscape of chronic hand eczema through advanced techniques like spatial transcriptomics and single-cell proteomics. It includes patients aged 18 to 65 with chronic hand eczema, assessing disease severity using validated scores and conducting skin biopsies for diagnosis confirmation. The research aims to identify distinct inflammatory cell subgroups and molecular markers that characterize the immune response in various subtypes of chronic hand eczema, potentially leading to more personalized treatment strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients affected with chronic hand eczema of endogenous and/or exogenous origin, age from 18 to 65 years
* Patients affected with eczema located on the hands for at least 3 months or with ≥ 2 disease flare-ups in the last year.
* Patients affected with atopic dermatitis affecting the hands and other areas of the body, provided the eczema lesions involve less than 30% of the body surface area.

Exclusion Criteria:

* Concurrent or previous treatment with immunosuppressants, except for short courses of systemic corticosteroids (less than one month of continuous treatment), or biologic agents that may affect the clinical aspects or progression of chronic hand eczema.
* Patients who have received systemic corticosteroids within one month prior to enrollment in the study.
* Patients using topical corticosteroids or calcineurin inhibitors within one week of study enrollment (this time frame is considered to provide a good balance between potential residual pharmacological effects and ethical considerations).
* Patients with chronic hand eczema of mixed etiology (e.g., allergic and atopic) or those considered "etiologically unclassifiable" will not be included in the data analysis.

Where it's running

• Fondazione Policlinico Universitario Agostino Gemelli IRCCS
  Rome, Italy Recruiting

Study contacts

• Principal investigator: Ketty Peris, Prof — Fondazione Policlinico Universitario Agostino Gemelli IRCCS
• Study coordinator: Ketty Peris, Prof
• Email: ketty.peris@policlinicogemelli.it
• Phone: +390630155284

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.