Exploring the Gut Microbiome's Role in Pain After Kidney Transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between gut microbiome composition, serum metabolites, and chronic pain in kidney transplant recipients (KTRs). It aims to identify specific microbial phenotypes and their association with pain levels, while also examining how diet and stress may influence these relationships. By integrating longitudinal data, the study seeks to enhance the understanding of host-microbial interactions that contribute to pain in this population. The findings could provide insights into potential biological mechanisms underlying pain after kidney transplantation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Receiving a kidney transplant at the University of Illinois Hospital \& Health Sciences System (UI Health) Transplant Center at the University of Illinois Chicago (UIC),
* Planning to receive a kidney transplant at the UI Health Transplant Center
* 18 years of age or older (adult), and
* Understand the study process and provide written informed consent to participate.

Exclusion Criteria:

* Having a history of colon cancer or an inflammatory bowel disease
* Planning to receive a multiorgan transplant (e.g., simultaneous pancreas and kidney transplant).
* Having a history of Clostridium difficile infection in the preceding 8 weeks.

Where it's running

• UI Health
  Chicago, Illinois, United States Recruiting

Study contacts

• Study coordinator: Mark Lockwood
• Email: lockmar@uic.edu
• Phone: 314-604-2050

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Overnight Temperature Regulation to Test Gut Health, Inflammation, and Circadian Rhythms

  This study tests whether two weeks of using the Eight Sleep Pod at night can improve gut bacteria balance, lower inflammation, and strengthen daily temperature and blood pressure rhythms in postmenopausal women and age-matched men with poor sleep.

  Recruiting Eight Sleep Inc. · Newton Center, Massachusetts · NCT07848594

• Egg intake and gut health, HDL, and immune markers in adults

  This study tests whether daily egg whites or whole eggs affect gut microbiome, HDL function, metabolism, and immune profiles in adults with a range of BMIs.

  Recruiting University of Connecticut · Storrs, Connecticut · NCT07844616

• Tiny Tummies: Milk vs. Oat Milk for Toddlers

  This 12‑month randomized study will test whether 12‑month‑old toddlers who drink daily cow’s milk dairy vs. oat milk dairy have better growth, sleep, neurocognitive outcomes, and gut microbiome by 24 months.

  Recruiting Arizona State University · Phoenix, Arizona · NCT07839156

• Probiotic supplementation to support gut health, immune response, and well-being in adults

  In this 8-week study, healthy adults with mild to moderate stress will take a probiotic supplement or placebo daily to see if it affects gut barrier function, immune markers, and well-being.

  Recruiting Orthomol Pharmazeutische Vertiebs GmbH · Trier · NCT07779265

• Combining 10-day Fasting with Fibre to Boost Gut Health

  This study tests whether adding dietary fibre to a 10-day fast improves gut microbiome function and metabolic health in adults with overweight or obesity.

  Recruiting Buchinger Wilhelmi Development & Holding GmbH · Überlingen, Baden-Wurttemberg · NCT07691736

• Daily kefir during mid-pregnancy to see if it helps prevent gestational diabetes

  Pregnant people will drink kefir daily from mid-pregnancy to see if it improves blood sugar and insulin, reduces gestational diabetes risk, and positively affects gut bacteria.

  Recruiting University of New Brunswick · Fredericton, New Brunswick · NCT07682077

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.