Exploring the genetic causes of mitral valve prolapse

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify genetic factors associated with mitral valve prolapse (MVP) by recruiting large families with a history of the condition and collecting DNA samples from 1,000-1,500 affected individuals. The researchers have already pinpointed two novel genetic loci on chromosomes 11 and 13 and are investigating altered genes in these regions. By conducting a genome-wide association study, the goal is to uncover the genes responsible for MVP, which could enhance understanding and treatment of the disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Mitral valve prolapse

Exclusion Criteria:

* Other mitral valve diseases

Where it's running

• Mass General Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: robert a levine, MD — Mass. General Hospital
• Study coordinator: Susan Slaugenhaupt, PhD
• Email: slaugenhaupt@chgr.mgh.harvard.edu
• Phone: 6176433217

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Predicting high-risk arrhythmic events in people with arrhythmic mitral valve prolapse

  This study tests a risk model to see which patients with arrhythmic mitral valve prolapse might need an ICD.

  Recruiting Oslo University Hospital · Oslo · NCT07830888

• AI and 3D ultrasound mapping of mitral valve prolapse shape and function.

  This project tests an automated AI system that uses intraoperative 3D transesophageal ultrasound to map mitral valve anatomy and create patient-specific biomechanical models for adults having surgery for degenerative mitral valve prolapse.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese · NCT07384871

• Korea VHD Echo Study: Real-World Practice of Aortic, Mitral, and Tricuspid Valves

  This study looks at how valvular heart disease is managed in Korea by reviewing echocardiograms and medical records from multiple centers to see patterns in disease progression and treatment.

  Recruiting at 2 sites Yonsei University · Seoul, Seoul and 1 other locations · NCT07068633

• Patient-centered decision-making for mitral valve prolapse treatment

  This study is trying to understand what patients with mitral valve prolapse and their doctors think about choosing between two treatment options, surgery or a less invasive procedure, to help improve how they make decisions together.

  Recruiting at 5 sites Northwell Health · Los Angeles, California and 4 other locations · NCT06738537

• Predicting heart muscle scarring in patients with mitral valve prolapse

  This study is trying to find out if a new scoring system can help identify patients with mitral valve prolapse who are at risk for heart muscle scarring and related problems using heart imaging.

  Recruiting Centro Cardiologico Monzino · Milan, Milan · NCT06341166

• Impact of mitral valve surgery on ventricular arrhythmias

  This study is testing how mitral valve surgery helps people with mitral valve prolapse and arrhythmias by looking at their heart health before and after the operation.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County · NCT06255457

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.