Exploring the genetic causes of mitral valve prolapse
Genetic Basis of Mitral Valve Prolapse
Massachusetts General Hospital · NCT01719211
This study is trying to find out if certain genes are linked to mitral valve prolapse by looking at DNA from families who have a history of the condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1500 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Massachusetts General Hospital (other) |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT01719211 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify genetic factors associated with mitral valve prolapse (MVP) by recruiting large families with a history of the condition and collecting DNA samples from 1,000-1,500 affected individuals. The researchers have already pinpointed two novel genetic loci on chromosomes 11 and 13 and are investigating altered genes in these regions. By conducting a genome-wide association study, the goal is to uncover the genes responsible for MVP, which could enhance understanding and treatment of the disease.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with mitral valve prolapse.
Not a fit: Patients with other mitral valve diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better prevention and treatment strategies for individuals genetically predisposed to mitral valve prolapse.
How similar studies have performed: Other studies have shown success in identifying genetic factors related to cardiovascular conditions, suggesting potential for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Mitral valve prolapse Exclusion Criteria: * Other mitral valve diseases
Where this trial is running
Boston, Massachusetts
- Mass General Hospital — Boston, Massachusetts, United States (RECRUITING)
Study contacts
- Principal investigator: robert a levine, MD — Mass. General Hospital
- Study coordinator: Susan Slaugenhaupt, PhD
- Email: slaugenhaupt@chgr.mgh.harvard.edu
- Phone: 6176433217
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Mitral Valve Prolapse, MVP, mitral valve