Exploring the genetic and epigenetic factors in chronic wounds

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational pilot study aims to investigate the genetic signatures associated with chronic wounds that do not heal properly. By analyzing debrided wound tissue and blood samples from patients at UPMC hospitals, researchers will compare genomic data to identify specific genetic and epigenetic factors that influence wound healing. The study will follow participants for 16 weeks, collecting data at multiple visits to better understand the individual genetic predispositions affecting healing outcomes. This research seeks to enhance treatment options by providing personalized genetic information for chronic wound management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Willing to comply with protocol instructions, including all study visits and study activities.
* Chronic wounds (\> than four weeks since onset)
* Clinically diagnosed diabetic or non-diabetic ulcer.
* For patients with multiple wounds, the largest wound will be used for the study.

Exclusion Criteria:

* Individuals who are deemed unable to understand the procedures, risks and benefits of the study,(i.e. unable to provide informed consent)
* Pregnant females (self-declared) or lactating
* Subjects with marked immunodeficiency (HIV/AIDS or immune-suppressive medications)
* Prisoners

Where it's running

• UPMC Wound Care Centers
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Chandan K Sen, PhD — University of Pittsburgh
• Study coordinator: Piya Das Ghatak, PhD, MS
• Email: piya.dasghatak@pitt.edu
• Phone: 412-648-8297

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.