Exploring the genetic and epigenetic factors in chronic wounds
Genetic and Epigenetic Basis of Chronic Wounds
This study is trying to find out how our genes affect the healing of chronic wounds by looking at tissue and blood samples from patients to improve treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 256 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | University of Pittsburgh Academic / other |
| Locations | 1 site (Pittsburgh, Pennsylvania) |
| Trial ID | NCT03793062 on ClinicalTrials.gov |
What this trial studies
This observational pilot study aims to investigate the genetic signatures associated with chronic wounds that do not heal properly. By analyzing debrided wound tissue and blood samples from patients at UPMC hospitals, researchers will compare genomic data to identify specific genetic and epigenetic factors that influence wound healing. The study will follow participants for 16 weeks, collecting data at multiple visits to better understand the individual genetic predispositions affecting healing outcomes. This research seeks to enhance treatment options by providing personalized genetic information for chronic wound management.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older with chronic wounds that have persisted for more than four weeks.
Not a fit: Patients who are pregnant, lactating, or have significant immunodeficiency may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective, personalized treatments for chronic wounds based on individual genetic profiles.
How similar studies have performed: While the genetic and epigenetic basis of chronic wounds is a relatively novel area of investigation, similar studies have shown promise in understanding other chronic conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Willing to comply with protocol instructions, including all study visits and study activities. * Chronic wounds (\> than four weeks since onset) * Clinically diagnosed diabetic or non-diabetic ulcer. * For patients with multiple wounds, the largest wound will be used for the study. Exclusion Criteria: * Individuals who are deemed unable to understand the procedures, risks and benefits of the study,(i.e. unable to provide informed consent) * Pregnant females (self-declared) or lactating * Subjects with marked immunodeficiency (HIV/AIDS or immune-suppressive medications) * Prisoners
Where this trial is running
Pittsburgh, Pennsylvania
- UPMC Wound Care Centers — Pittsburgh, Pennsylvania, United States (Recruiting)
Study contacts
- Principal investigator: Chandan K Sen, PhD — University of Pittsburgh
- Study coordinator: Piya Das Ghatak, PhD, MS
- Email: piya.dasghatak@pitt.edu
- Phone: 412-648-8297
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.