Exploring the Function of the Human Spleen and Its Role in Blood Disorders
Official title: Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations
Run by Assistance Publique - Hôpitaux de Paris · NCT06418256 · Data updated 2026-11-12
This study looks at how the spleen works and its role in blood disorders, especially in patients who have had their spleen removed, to see if new treatments can help improve blood cell health.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 5 sites (Clichy and 4 other locations) |
| Status | Recruiting |
| Started | October 16, 2016 |
| Main results expected | October 16, 2031 |
| Study ends | October 16, 2031 |
| Registry record updated | September 15, 2025 |
| Trial ID | NCT06418256 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adult patients scheduled for splenic interventions such as spleno-pancreatectomy or splenectomy.
✕Probably not a fit
Patients who refuse to allow the collection of their spleen and blood volume will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the physiology of the human spleen and its involvement in various blood disorders, particularly focusing on splenectomy patients. By analyzing splenic clearance of abnormal cells through ex-vivo perfusion experiments, the research aims to clarify the spleen's role in diseases like malaria and assess the potential of treatments that can alter the spleen's perception of blood cells. Blood samples collected from patients undergoing splenic interventions will be used for further analysis of splenic filtration mechanisms and immune responses.
Why it matters
Potential benefit: If successful, this study could enhance understanding of splenic function and lead to improved treatments for blood-related diseases.
How similar studies have gone: While the study explores novel aspects of splenic function, similar approaches have shown promise in understanding splenic roles in other diseases.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients * Patient requiring left splenopancreectomy or planned splenectomy regardless of the method or indication Exclusion Criteria: \- The patient notified his doctor of his refusal to recover his spleen and blood volume
Where it's running
-
Hôpital Beaujon
Clichy, France Recruiting -
Hôpital Saint Antoine
Paris, France Recruiting -
Hôpital Pitié Salpêtrière
Paris, France Recruiting -
Hôpital Necker-Enfants Malades
Paris, France Recruiting -
Institut Pasteur
Paris, France Active not recruiting
Study contacts
- Principal investigator: Pierre Buffet, MD, PhD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Pierre Buffet, MD, PhD
- Email: pierre.buffet@aphp.fr
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Italian questionnaire to measure knowledge and vaccination attitudes in people without a spleen
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Laparoscopic partial removal of the spleen for hypersplenism in cirrhosis.
This test tries whether removing part of the spleen by laparoscopy improves immune function and recovery in people with cirrhosis and hypersplenism.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.