Exploring the Function of the Human Spleen and Its Role in Blood Disorders
Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations
Assistance Publique - Hôpitaux de Paris · NCT06418256
This study looks at how the spleen works and its role in blood disorders, especially in patients who have had their spleen removed, to see if new treatments can help improve blood cell health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris (other) |
| Locations | 5 sites (Clichy and 4 other locations) |
| Trial ID | NCT06418256 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the physiology of the human spleen and its involvement in various blood disorders, particularly focusing on splenectomy patients. By analyzing splenic clearance of abnormal cells through ex-vivo perfusion experiments, the research aims to clarify the spleen's role in diseases like malaria and assess the potential of treatments that can alter the spleen's perception of blood cells. Blood samples collected from patients undergoing splenic interventions will be used for further analysis of splenic filtration mechanisms and immune responses.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients scheduled for splenic interventions such as spleno-pancreatectomy or splenectomy.
Not a fit: Patients who refuse to allow the collection of their spleen and blood volume will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of splenic function and lead to improved treatments for blood-related diseases.
How similar studies have performed: While the study explores novel aspects of splenic function, similar approaches have shown promise in understanding splenic roles in other diseases.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients * Patient requiring left splenopancreectomy or planned splenectomy regardless of the method or indication Exclusion Criteria: \- The patient notified his doctor of his refusal to recover his spleen and blood volume
Where this trial is running
Clichy and 4 other locations
- Hôpital Beaujon — Clichy, France (RECRUITING)
- Hôpital Saint Antoine — Paris, France (RECRUITING)
- Hôpital Pitié Salpêtrière — Paris, France (RECRUITING)
- Hôpital Necker-Enfants Malades — Paris, France (RECRUITING)
- Institut Pasteur — Paris, France (ACTIVE_NOT_RECRUITING)
Study contacts
- Principal investigator: Pierre Buffet, MD, PhD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Pierre Buffet, MD, PhD
- Email: pierre.buffet@aphp.fr
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Splenectomy, Spleen, Human splenic physiology, Splenic clearance, Splenic filtration mechanisms, Perfusion experiments, Role of the spleen in the adaptive immune response, Genetic spleen mechanisms