Exploring the extremes of coronary artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates two distinct groups of patients with coronary artery disease (CAD): those who have significant CAD despite low risk factors and those with multiple risk factors but little to no CAD. The researchers aim to identify molecular markers that may contribute to or protect against acute coronary syndrome (ACS) by analyzing genetic, blood, and atherosclerotic samples from these extreme patient groups. Utilizing single-cell RNA sequencing and a multi-omics approach, the study seeks to uncover insights into the mechanisms underlying these contrasting phenotypes. The findings could enhance understanding of CAD and inform future therapeutic strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Group 1:

1. Evidence of significant CAD a. Coronary angiogram or CT coronary angiogram with documented stenosis \>=50% in left main or \>=70% in major epicardial vessel or major branches (LAD, LCX, RCA)

   AND all of the following
2. Age \</= 45 for males and \</= 50 for females
3. Absence of diabetes mellitus
4. Absence of tobacco use
5. No prior CVA or PAD

Group 2

1. Evidence of significant CAD

   1. Coronary angiogram or CT coronary angiogram with documented stenosis \>=50% in left main or \>=70% in major epicardial vessel or major branches (LAD, LCX, RCA)

   AND all of the following
2. Age \</= 45 for males and \</= 50 for females
3. Absence of diabetes mellitus
4. Absence of tobacco use
5. No prior CVA or PAD

Group 3 1. Evidence of significant CAD with one of the following:

1. age\>65
2. Diabetes mellitus
3. End Stage Renal Failure (ESRF)
4. Framingham risk score \>10%

Group 4

1\. No evidence of significant CAD and all of the following

1. Age \<55 for males, \<65 for females
2. Absence of diabetes mellitus
3. Absence of CKD
4. Absence of tobacco use

Exclusion Criteria:

1. Prior history of cancer (excludes pre-cancerous lesions)
2. Expected life expectancy less than 1 year
3. Known autoimmune disease
4. Psychiatric illness
5. Chronic lung disease requiring long term medications or oxygen
6. Chronic infective disease, including tuberculosis, hepatitis B and C; and HIV
7. Inability to comply with study protocol
8. Any other acute or chronic medical or physical condition deemed by the investigator to affect study outcomes

Where it's running

• National Heart Centre Singapore
  Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Khyung Keong Yeo — National Heart Centre
• Study coordinator: Aishah Toh
• Email: aishah.toh@nhcs.com.sg
• Phone: 67042282

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.