Exploring the effects of remote ischemic preconditioning on stroke recovery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of chronic remote ischemic preconditioning (RIC) on the collateral circulation in patients who have experienced ischemic strokes due to large artery atherosclerosis. The study is designed as a prospective, randomized, and blinded multicenter trial, enrolling patients with poor collateral compensation more than one month after their stroke. Participants will be randomly assigned to either receive RIC treatment alongside standard care or only standard care for one year. The primary outcome is the improvement in collateral status assessed through digital subtraction angiography (DSA) after 12 months.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. Age over 40 years old;
* 2\. Diagnosed with ischemic stroke (including TIA and cerebral infarction), with onset time of more than 1 month;
* 3\. Culprit arteries are the large arteries of the anterior circulation with atherosclerotic stenosis (≥50%) or occlusion;
* 4\. ASITN/SIR collateral circulation of 0-3 based on DSA evaluation;
* 5\. First onset or prior onset with no significant sequelae (mRS ≤ 2);
* 6\. Those who are not expected to undergo angioplasty within 12 months (judged by the doctor or decided by patients and/or their representatives);
* 7\. The availability of informed consent.

Exclusion Criteria:

* 1\) Patients with severe infection or serious diseases such as liver, kidney, hematopoietic system, endocrine system, etc.;
* 2\) Patients with a history of stroke and severe sequelae (mRS≥3);
* 3\) arterial stenosis due to aortic dissection, moyamoya disease; Any known vasculitic disease; herpes zoster, varicella-zoster or other viral infections with vascular lesions; neurosyphilis; other intracranial infections; any intracranial artery stenosis associated with hypercytosis of cerebrospinal fluid; radiation-induced vascular lesions; myofiber dysplasia; sickle cell disease; neurofibromas; benign vascular lesions of the central nervous system; postpartum vascular disease; stenosis of the intracranial arteries due to vasospasm or thrombosm;
* 4\) Uncontrolled severe hypertension (systolic pressure≥180mmHg or diastolic pressure≥110 mmHg after drug treatment) ;
* 5\) Subclavian artery stenosis ≥50% or subclavian artery steal syndrome;
* 6\) Patients with intracranial hemorrhage (parenchymal hemorrhage, subarachnoid hemorrhage, subdural/epidural hemorrhage) within 90 days before enrollment;
* 7\) Intracranial tumor, arteriovenous malformation, or aneurysm;
* 8\) Patients with severe hematologic diseases or severe coagulation abnormalities;
* 9\) Retinal hemorrhage or visceral hemorrhage within 30 days;
* 10\) Those who are expected to undergo major surgery (including femoral artery, cardiac, aortic or carotid artery surgery) within 30 days before enrollment or within 12 months after enrollment;
* 11\) Those who have received stent implantation, angioplasty or other related medical devices for the target diseased blood vessels, or those who are expected to undergo the above treatments within 12 months after enrollment;
* 12\) Any contraindication for remote ischemic adaptation: the upper limb has serious soft tissue injury, fracture or vascular injury, distal upper limb perivascular lesions, etc.
* 13\) Damage and lesions in the cerebral veins;
* 14\) Pregnant or lactating women;
* 15\) Those who are participating in other clinical trials within 3 months;
* 16\) Life expectancy is less than 1 year
* 17\) Patients not suitable for this clinical studies considered by researcher

Where it's running

• General Hospital of Northern Theater Command
  Shenyang, China Recruiting

Study contacts

• Study coordinator: Ziai Zhao
• Email: zhaoziai@hotmail.com
• Phone: 18304098115

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Paired VNS: How the Brain and Pupils Respond in Stroke Patients

  This study tests real-time physiologic responses to paired VNS in adults with chronic motor impairment after ischemic stroke to help tailor dosing.

  Recruiting MGH Institute of Health Professions · Boston, Massachusetts · NCT07922200

• NeuroAiD test in mild to moderate ischemic stroke patients

  This study tests whether adding MLC901 (NeuroAiD II) to standard stroke care helps adults who recently had an ischemic stroke recover better than standard care alone.

  Recruiting Phase 4 EVD Pharmacy and Medical Company Limited · Ho Chi Minh City · NCT07828210

• Using IMPROVE to guide carotid revascularisation decisions

  This trial tests whether using the IMPROVE MRI-based score to select patients for carotid revascularisation is as good as standard care based mainly on stenosis degree, among people who have had a recent stroke or TIA due to carotid disease.

  Recruiting Maastricht University Medical Center · Arnhem, Gelderland and 9 other locations · NCT07556887

• High-intensity interval versus moderate continuous exercise for stroke-related muscle loss

  This will test whether high-intensity interval training (HIIT) or moderate-intensity continuous training (MCIT) better helps people 1–6 months after an ischemic stroke who have muscle loss regain muscle mass, strength, walking ability, and quality of life.

  Recruiting Fenerbahce University · Istanbul, Ataşehir · NCT07456956

• Test of adding a very low-dose edoxaban to standard antiplatelet therapy to prevent another stroke in adults 75 and older

  This trial tests whether adding a tiny amount of edoxaban to aspirin or clopidogrel can better prevent a second stroke in people aged 75+ who recently had an ischemic stroke.

  Recruiting Phase 3 Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07454707

• HR-MRI–Directed Tirofiban Therapy for Late-Window ICAS-LAA Stroke

  We’re testing whether tirofiban plus dual antiplatelet therapy, guided by high-resolution MRI of the brain’s blood vessels, can help people with intracranial large-artery atherosclerosis strokes that begin more than 24 hours after onset.

  Recruiting Phase 3 Weifang Medical University · Weifang, China/Shandong Province · NCT07379190

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.