Exploring the effects of obstructive sleep apnea on vascular surgery outcomes
Obstructive Sleep Apnea as a Remote Ischemic Preconditioning in Patients Scheduled for Aorto-bifemoral Bypass Surgery
St. Anne's University Hospital Brno, Czech Republic · NCT04630535
This study is testing how obstructive sleep apnea might affect recovery and complications in patients having surgery to repair an abdominal aortic aneurysm.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | St. Anne's University Hospital Brno, Czech Republic (other) |
| Locations | 1 site (Brno, Czech Republic) |
| Trial ID | NCT04630535 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the relationship between obstructive sleep apnea (OSA) and ischemia-reperfusion (I/R) injury in patients undergoing elective aortobifemoral bypass surgery for abdominal aortic aneurysm repair. Patients will be assessed for OSA severity using polygraphy and questionnaires prior to surgery. The study will monitor postoperative complications and specific markers of I/R at various time points following surgery to determine if OSA has a protective effect against I/R injury. The findings could provide insights into optimizing surgical outcomes for patients with OSA.
Who should consider this trial
Good fit: Ideal candidates for this study are patients scheduled for elective aortobifemoral bypass surgery who may or may not have obstructive sleep apnea.
Not a fit: Patients requiring emergent surgery, those undergoing re-operations, or those with known OSA on CPAP treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved postoperative outcomes for patients with obstructive sleep apnea undergoing vascular surgery.
How similar studies have performed: While studies on ischemic preconditioning have shown mixed results, the specific focus on OSA's protective effects in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients scheduled for elective aorto-bifemoral bypass (AAA and Leriche syndrome patients) Exclusion Criteria: * emergent surgery * aorto-bifemoral bypass using deep vein graft * re-operations * known OSA with CPAP treatment
Where this trial is running
Brno, Czech Republic
- St. Anne's University Hospital Brno — Brno, Czech Republic, Czechia (RECRUITING)
Study contacts
- Principal investigator: Ivan Cundrle, M.D., Ph.D. — St. Anne's University Hospital in Brno
- Study coordinator: Ivan Cundrle, M.D., Ph.D.
- Email: ivan.cundrle@fnusa.cz
- Phone: 00420543182553
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Obstructive Sleep Apnea, Vascular Aneurysm, Ischemia Reperfusion Injury, remote preconditioning