Exploring the effects of lidocaine on stress responses during surgery
Effects of Intravenous Lidocaine Infusion on Stress Response in Patients Undergoing Abdominal Surgery During Perioperative Anesthesia and Its Correlation With Serum Orphanin FQ (N/OFQ)
This study tests if giving lidocaine during surgery can help reduce stress responses, like high blood pressure, in patients having elective abdominal surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Second Hospital of Shanxi Medical University Academic / other |
| Locations | 1 site (Taiyuan, Shanxi) |
| Trial ID | NCT05899127 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the impact of intravenous lidocaine administration during the perioperative period on stress responses in patients undergoing elective abdominal surgery. The study aims to understand the mechanism by which lidocaine may reduce stress indicators such as blood pressure and inflammatory markers, as well as its relationship with serum N/OFQ levels. Patients will be randomized to receive either lidocaine or a saline solution during anesthesia, and various physiological and biochemical parameters will be monitored throughout the procedure. Blood samples will be collected at specific intervals to assess changes in stress-related indicators.
Who should consider this trial
Good fit: Ideal candidates for this study are ASA I-II patients undergoing elective abdominal surgery with an anesthesia duration of less than 1-2 hours.
Not a fit: Patients with significant comorbidities such as hypertension, coronary heart disease, diabetes, or those with a history of airway difficulties may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of stress responses in surgical patients, potentially enhancing recovery and reducing postoperative complications.
How similar studies have performed: While the use of lidocaine in perioperative settings has been explored, this specific investigation into its relationship with serum N/OFQ and stress responses is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA I-II * Patients undergoing elective abdominal surgery with anesthesia duration less than 1-2h Exclusion Criteria: * It is estimated that patients with difficulty in tracheal intubation (poor head and neck mobility, history of airway surgery, history of OSAHS, nail to chin distance\<6cm, Malampati grade 3 and above, mouth opening\<2.5cm, obesity (BMI\>30kg · m-2), etc.) * Hypertension patients (clinically diagnosed as hypertension), coronary heart disease patients (with typical symptoms of angina pectoris and exclusion of aortic valve disease, clear history of old myocardial infarction, clear history of acute myocardial infarction) * Patients with diabetes and central nervous system diseases * Patients with long-term use of sedatives or antidepressants * Patients with a history of alcoholism or drug dependence * Asthma or reactive airway disease * Shock, severe hypotension, severe arrhythmia and other adverse events occurred during the operation
Where this trial is running
Taiyuan, Shanxi
- Second of Shanxi Medical University — Taiyuan, Shanxi, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.