Exploring the effects of exercise on inflammation in Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how exercise influences inflammation in older adults, particularly those with Parkinson's disease (PD). It aims to understand the neuroprotective effects of aerobic exercise on slowing the progression of PD, which is characterized by neuroinflammation leading to neuron cell death. Participants will engage in 30 minutes of moderate aerobic exercise, with the goal of assessing improvements in symptoms and overall quality of life. The research focuses on the potential of exercise to mitigate the pathological mechanisms associated with PD.

Why it matters

Who can join: the full rules

Inclusion criteria for PwP:

* 30-85 years old
* Neurologist-diagnosed PD
* Able to participate in 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks per self-report.

Inclusion criteria for controls:

* 30-85 years old
* No major medical diagnoses
* Able to participate in 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks per self-report.

Exclusion Criteria for both PD group and controls:

* Diagnoses, identified by self-report, that would preclude exercise participation (e.g., heart arrhythmias, uncontrolled blood pressure, exercise-induced asthma).
* Those not deemed ready for exercise participation. Participants will be screened for exercise participation using the Physical Activities Readiness Questionnaire + which is used as a screening tool for all ages to identify risk factors that would clear someone for participation in moderate physical exercise.
* Those with dementia will be excluded because there are self-report questionnaires in this study. This will be identified using the Montreal Cognitive Assessment and a score at or below a 21. Participants with mild cognitive impairment and no impairment will be included.

Where it's running

• Gait and Balance Laboratory, 217 Bigelow Health Sciences Building, UNLV
  Las Vegas, Nevada, United States Recruiting

Study contacts

• Principal investigator: Merrill Landers, DPT, PhD — University of Nevada, Las Vegas
• Study coordinator: Merrill Landers, DPT, PhD
• Email: merrill.landers@unlv.edu
• Phone: 17028951377

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.