Exploring the effects of exercise on inflammation in Parkinson's disease
Exploring the Biological Basis for Exercise Neuroprotection in Parkinson's Disease
This study is testing if regular aerobic exercise can help reduce inflammation and improve symptoms for older adults with Parkinson's disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 30 Years to 85 Years |
| Sex | All |
| Sponsor | University of Nevada, Las Vegas Academic / other |
| Locations | 1 site (Las Vegas, Nevada) |
| Trial ID | NCT05854524 on ClinicalTrials.gov |
What this trial studies
This study investigates how exercise influences inflammation in older adults, particularly those with Parkinson's disease (PD). It aims to understand the neuroprotective effects of aerobic exercise on slowing the progression of PD, which is characterized by neuroinflammation leading to neuron cell death. Participants will engage in 30 minutes of moderate aerobic exercise, with the goal of assessing improvements in symptoms and overall quality of life. The research focuses on the potential of exercise to mitigate the pathological mechanisms associated with PD.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 30-85 with a neurologist-diagnosed case of Parkinson's disease who can participate in moderate aerobic exercise.
Not a fit: Patients with major medical conditions that preclude exercise participation or those with dementia may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a non-pharmacological approach to slowing the progression of Parkinson's disease and improving patient quality of life.
How similar studies have performed: Previous studies have shown that exercise can improve symptoms and quality of life in Parkinson's disease, suggesting that this approach has potential based on existing evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria for PwP: * 30-85 years old * Neurologist-diagnosed PD * Able to participate in 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks per self-report. Inclusion criteria for controls: * 30-85 years old * No major medical diagnoses * Able to participate in 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks per self-report. Exclusion Criteria for both PD group and controls: * Diagnoses, identified by self-report, that would preclude exercise participation (e.g., heart arrhythmias, uncontrolled blood pressure, exercise-induced asthma). * Those not deemed ready for exercise participation. Participants will be screened for exercise participation using the Physical Activities Readiness Questionnaire + which is used as a screening tool for all ages to identify risk factors that would clear someone for participation in moderate physical exercise. * Those with dementia will be excluded because there are self-report questionnaires in this study. This will be identified using the Montreal Cognitive Assessment and a score at or below a 21. Participants with mild cognitive impairment and no impairment will be included.
Where this trial is running
Las Vegas, Nevada
- Gait and Balance Laboratory, 217 Bigelow Health Sciences Building, UNLV — Las Vegas, Nevada, United States (Recruiting)
Study contacts
- Principal investigator: Merrill Landers, DPT, PhD — University of Nevada, Las Vegas
- Study coordinator: Merrill Landers, DPT, PhD
- Email: merrill.landers@unlv.edu
- Phone: 17028951377
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.