Exploring the effects of aging on heart function and fibrosis
Myocardial Fibrosis and Changes of Myocardial Function Related to Aging
NA · Hospices Civils de Lyon · NCT03064503
This study is testing how aging affects heart function and fibrosis in healthy people to better understand their heart health as they get older.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospices Civils de Lyon (other) |
| Locations | 1 site (Saint Etienne) |
| Trial ID | NCT03064503 on ClinicalTrials.gov |
What this trial studies
This study investigates how myocardial fibrosis affects heart function in healthy individuals as they age. It aims to understand the relationship between changes in heart function and measures of fibrosis using advanced Magnetic Resonance Imaging (MRI) techniques, as well as blood and skin tests. Participants will undergo blood sampling, MRI scans, and skin auto-fluorescence assessments to gather comprehensive data on their cardiac health. The study focuses on individuals with no significant cardiovascular risk factors to ensure accurate results.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults aged 40 and older who engage in limited physical activity and have no significant cardiovascular risk factors.
Not a fit: Patients with a history of cardiovascular diseases, arrhythmias, or other significant health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of heart health in aging populations and lead to improved strategies for monitoring and managing cardiac function.
How similar studies have performed: While the specific approach of this study may be novel, similar studies have shown that understanding myocardial fibrosis can provide valuable insights into heart health.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * physical activity ≤ 3 x(30') per week * no history of smoking, diabetes, myocardial infarction, heart failure, hypertension (\<140 or \<90 mmHg) and no anti-hypertensive or cardiovascular-related medications * no familial history of early myocardial ischemia * body mass index (BMI) \<30kg/m2 * normal routine lipid blood analysis * glycemia \<1.26g/l * normal electrocardiogram (ECG) Exclusion Criteria: * arrhythmia * hepatic insufficiency * pregnancy * claustrophobia * MRI contrast allergy, * general contraindications to MRI such as pacemaker, etc.
Where this trial is running
Saint Etienne
- Département de Radiologie, CHU Saint-Etienne - Hôpital Nord — Saint Etienne, France (RECRUITING)
Study contacts
- Principal investigator: Pierre CROISILLE, MD, PhD — CHU SAINT-ETIENNE
- Study coordinator: Pierre CROISILLE, MD, PhD
- Email: croisille@creatis.insa-lyon.fr
- Phone: +33 477 127 584
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy, myocardial fibrosis, cardiac function, ageing