Exploring the effects of a placebo probiotic on gut health and well-being

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates whether positive expectations of receiving a probiotic supplement, which is actually a placebo, can improve gastrointestinal symptoms and enhance overall well-being in healthy individuals experiencing mild gastrointestinal distress. Participants will be divided into two groups: one receiving a deceptive placebo and another receiving no treatment initially. After a waiting period, the control group will be offered the placebo in an open-label manner, where they will be informed that the pills are inert. The study aims to compare the effects of the deceptive placebo against the open-label placebo and assess any significant improvements in symptoms and well-being.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 20 and 65
* Individuals with mild gastrointestinal symptoms (e.g., digestive issues, acid reflux, constipation) such that normal every-day activities are not severly compromised.

Exclusion Criteria:

* Individuals with a diagnosis of functional gastrointestinal disorders (e.g., irritable bowel syndrome, ulcerative colitis, chronic inflammatory bowel diseases).
* Individuals suffering from neurodegenerative diseases and/or psychiatric conditions
* Individuals taking probiotic supplementation at the time of enrollment in the study

Where it's running

• Catholic University of the Sacred Heart
  Milan, Italy Recruiting

Study contacts

• Study coordinator: Diletta Barbiani
• Email: diletta.barbiani@unicatt.it
• Phone: +393338059338

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.