Exploring taste functions in Parkinson's and Lewy body diseases
Official title: Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis
Run by Centre Hospitalier Universitaire Dijon · NCT06439355 · Data updated 2026-11-12
This study is testing how taste works in healthy people compared to those with early Parkinson's disease and Lewy body disease to see if there are any differences.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 66 (estimated) |
| Sponsor | Centre Hospitalier Universitaire Dijon Academic / other |
| Locations | 1 site (Dijon) |
| Status | Recruiting |
| Started | May 27, 2024 |
| Main results expected | May 2027 |
| Study ends | May 2027 |
| Registry record updated | October 7, 2026 |
| Trial ID | NCT06439355 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include healthy adults and patients diagnosed with early Parkinson's disease or incipient Lewy body disease, all meeting specific inclusion criteria.
✕Probably not a fit
Patients who are pregnant, under legal protection, or have significant cognitive impairments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to investigate the taste functions of three groups: healthy volunteers, patients with early Parkinson's disease, and patients with incipient Lewy body disease. By analyzing gustatory evoked potentials, the researchers will compare the results across these groups alongside various nutritional, motor, and cognitive data. The goal is to identify differences in cortical processing of taste sensory information related to the progression of these diseases.
Why it matters
Potential benefit: If successful, this study could enhance understanding of sensory processing in Parkinson's and Lewy body diseases, potentially leading to improved diagnostic and therapeutic strategies.
How similar studies have gone: While the specific approach of analyzing gustatory evoked potentials in these conditions may be novel, similar studies have shown promise in understanding sensory processing in neurodegenerative diseases.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Healthy volunteers: * Person who has given written consent * Adult * Enrolled in the national register of healthy volunteers * Fasting \> 2 hours before PEG measurement * Body Mass Index (BMI) \< 30 kg/m². * No cognitive complaints and normal neurological assessment Patients with idiopathic Parkinson's disease: * Person who has given written consent * Adult * Fasting \> 2 hours before PEG measurement * Body Mass Index (BMI) \< 30 kg/m². * Diagnostic criteria for established or probable IPD Patients with Lewy body disease: * Person who has given written consent * Adult * Fasting \> 2 hours prior to PEG measurement * Body Mass Index (BMI) \< 30 kg/m². * Diagnostic criteria for probable or possible LBD Exclusion Criteria: * Non-affiliated to national health insurance * Person under legal protection (curatorship, guardianship) * Person subject to a court order * Pregnant, parturient or breast-feeding women * Major unable to give consent * MMSE score \< 15 and/or MoCA \< 10 * Known infection with COVID-19 in the 6 months prior to inclusion * Active smoker (\> 4 cigarettes per day on a regular basis) * Subject with pacemaker (contraindication for bioelectrical impedancemetry) * Diabetic (type 1 or type 2) * Taking medication (in progress at the time of the study) that interferes with gustation
Where it's running
-
Chu Dijon Bourgogne
Dijon, France Recruiting
Study contacts
- Study coordinator: Vincent SCHNEIDER
- Email: vincent.schneider@chu-dijon.fr
- Phone: 03.80.29.30.89
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.