Exploring taste function in patients with cognitive disorders
Single-center Prospective Longitudinal Study of Taste in Patients With Cognitive Disorders at Different Stages of Severity (Isolated Cognitive Complaint, Minor or Major Neurocognitive Alzheimer-type Disorders) by Analysis of Gustatory Evoked Potentials
NA · Centre Hospitalier Universitaire Dijon · NCT05888961
This study is testing how taste function changes in people with different levels of cognitive issues, including those with mild Alzheimer's, to see if it can help spot early signs of the disease.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 72 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire Dijon (other) |
| Locations | 1 site (Dijon) |
| Trial ID | NCT05888961 on ClinicalTrials.gov |
What this trial studies
This study aims to investigate gustatory function and its progression in four groups: healthy individuals, those with isolated cognitive complaints, individuals with minor neurocognitive disorders, and patients with mild to moderate Alzheimer-type major neurocognitive disorders. Participants will undergo subjective taste tests, gustatory evoked potential assessments, and nutritional evaluations through blood tests and body composition measurements. The goal is to identify early taste disorders associated with cognitive decline, potentially aiding in the early diagnosis and management of Alzheimer's disease.
Who should consider this trial
Good fit: Ideal candidates include adults with varying stages of cognitive disorders, including healthy individuals and those with isolated cognitive complaints or diagnosed neurocognitive disorders.
Not a fit: Patients with severe cognitive impairment or those who do not meet the study's specific diagnostic criteria may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier diagnosis and better management of Alzheimer's disease through the identification of taste disorders.
How similar studies have performed: While the exploration of gustatory function in cognitive disorders is a relatively novel approach, similar studies have shown promise in linking sensory functions to cognitive health.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Person who has given oral consent. * For patients with mild to moderate Alzheimer\'s disease, the primary caregiver and the patient will be asked to provide oral consent * Person of legal age * Body Mass Index (BMI) \< 30 kg/m². * For the healthy group: absence of cognitive complaints and normal neurological assessment * Patients meeting the criteria for isolated cognitive complaint: presence of cognitive complaint but normal neuropsychological evaluation * Patients meeting diagnostic criteria for minor cognitive impairment: imaging (brain MRI) and neuropsychological assessment with a Clinical Dementia Rating (CDR) score of 0.5 * Patients meeting diagnostic criteria for mild to moderate Alzheimer\'s disease: imaging (brain MRI), neuropsychobiological criteria (consultation with neuropsychological assessment, CSF biomarkers), MMSE score ≥ 20 and CDR score of 1 or 1.5 * Fasting for at least 2 hours before GEP measurement Exclusion Criteria: * MMSE score\<15 * Known COVID-19 infection within 6 months prior to inclusion * Person not affiliated to national health insurance system * Person under a legal protection measure (curatorship, guardianship) * Person subject to a measure of legal protection * Pregnant, parturient or breastfeeding women * Subjects with a pacemaker (contraindication to bioelectrical impedance measurement) * Adult unable to express consent or to perform cognitive tests. * Active smoker (\> 4 cigarettes per day on a regular basis) * Diabetic subject (type 1 or type 2) * Subject with acute or chronic ENT disease * Treatment interfering with gustation * Brain MRI showing another cause of neurocognitive disorder (except for vascular lesions Fazekas 1 accepted)
Where this trial is running
Dijon
- Chu Dijon Bourgogne — Dijon, France (RECRUITING)
Study contacts
- Study coordinator: Agnès JACQUIN-PIQUES
- Email: agnes.jacquin-piques@chu-dijon.fr
- Phone: 03.80.29.37.54
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cognitive Disorders