Clinical trial Recruiting at 1 site Observational Ages 18 and up

Exploring survival outcomes of a targeted therapy in specific lung cancer mutations

Official title: Survival Outcome of EGFR-TKI in Uncommon EGFR Mutant Advanced Non-small Cell Lung Cancer in China

Run by Hunan Province Tumor Hospital · NCT04324164 · Data updated 2026-11-12

This study is testing how well a new lung cancer treatment works for patients in China with rare EGFR mutations who haven't had other cancer treatments yet.

More Non-Small Cell Lung Cancer trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment800 (estimated)
SponsorHunan Province Tumor Hospital
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Changsha, Hunan)
StatusRecruiting
StartedMarch 24, 2020
Main results expectedDecember 24, 2025
Study endsDecember 24, 2027
Registry record updatedJanuary 27, 2025
Trial IDNCT04324164 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older with advanced non-squamous non-small cell lung cancer confirmed by histopathology and specific uncommon EGFR mutations.

Probably not a fit

Patients with contraindications to chemotherapy or those who are pregnant or breastfeeding may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the survival outcomes of third-generation EGFR-TKI treatment in patients with uncommon EGFR mutations in advanced non-small cell lung cancer (NSCLC) in China. The study focuses on patients with specific mutations such as EGFR G719X and exon 20 insertions who have not received prior anti-cancer treatments. By analyzing the effectiveness of EGFR-TKI in this unique patient population, the study aims to provide insights into treatment options for those with uncommon mutations.

Why it matters

Potential benefit: If successful, this study could provide valuable information on effective treatment options for patients with uncommon EGFR mutations in advanced NSCLC.

How similar studies have gone: While there have been studies on EGFR-TKI in common mutations, this specific focus on uncommon mutations is relatively novel and less explored.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18,Advanced Non-squamous Non-small Cell Lung Cancer Confirmed by Histopathology

  * Uncommon EGFR Mutant Advanced NSCLC

Exclusion Criteria:

* Patients with contraindication of chemotherapy
* Pregnant or breast feeding women

Where it's running

  • Yongchang Zhang
    Changsha, Hunan, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.