Exploring survival outcomes of a targeted therapy in specific lung cancer mutations
Official title: Survival Outcome of EGFR-TKI in Uncommon EGFR Mutant Advanced Non-small Cell Lung Cancer in China
Run by Hunan Province Tumor Hospital · NCT04324164 · Data updated 2026-11-12
This study is testing how well a new lung cancer treatment works for patients in China with rare EGFR mutations who haven't had other cancer treatments yet.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 800 (estimated) |
| Sponsor | Hunan Province Tumor Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Changsha, Hunan) |
| Status | Recruiting |
| Started | March 24, 2020 |
| Main results expected | December 24, 2025 |
| Study ends | December 24, 2027 |
| Registry record updated | January 27, 2025 |
| Trial ID | NCT04324164 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older with advanced non-squamous non-small cell lung cancer confirmed by histopathology and specific uncommon EGFR mutations.
✕Probably not a fit
Patients with contraindications to chemotherapy or those who are pregnant or breastfeeding may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the survival outcomes of third-generation EGFR-TKI treatment in patients with uncommon EGFR mutations in advanced non-small cell lung cancer (NSCLC) in China. The study focuses on patients with specific mutations such as EGFR G719X and exon 20 insertions who have not received prior anti-cancer treatments. By analyzing the effectiveness of EGFR-TKI in this unique patient population, the study aims to provide insights into treatment options for those with uncommon mutations.
Why it matters
Potential benefit: If successful, this study could provide valuable information on effective treatment options for patients with uncommon EGFR mutations in advanced NSCLC.
How similar studies have gone: While there have been studies on EGFR-TKI in common mutations, this specific focus on uncommon mutations is relatively novel and less explored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18,Advanced Non-squamous Non-small Cell Lung Cancer Confirmed by Histopathology * Uncommon EGFR Mutant Advanced NSCLC Exclusion Criteria: * Patients with contraindication of chemotherapy * Pregnant or breast feeding women
Where it's running
-
Yongchang Zhang
Changsha, Hunan, China Recruiting
Study contacts
- Principal investigator: Yongchang Zhang, MD — Hunan Cancer Hospital
- Study coordinator: Yongchang Zhang, MD
- Email: zhangyongchang@csu.edu.cn
- Phone: +8613873123436
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.