Exploring nerve cell growth in children with Hirschsprung's Disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on children diagnosed with Hirschsprung's Disease, a condition where nerve cells are absent in the lower bowel, leading to severe complications if untreated. Researchers aim to investigate the presence of nerve stem cells in the bowel and their potential to develop into functional nerve cells, which could improve bowel function. By comparing nerve stem cells from affected and unaffected bowel regions, the study seeks to understand their growth and development into neurospheres. This could pave the way for innovative treatments that address the underlying nerve deficiencies in Hirschsprung's Disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

• Any child undergoing therapeutic intestinal resection (but specifically those in which it is not necessary for all resected tissue to be sent for histopathological analysis, as no additional tissue will be removed for research purposes).

Exclusion Criteria:

• None

Where it's running

• Alder Hey Children's NHS Foundation Trust
  Liverpool, Merseyside, United Kingdom Recruiting

Study contacts

• Study coordinator: Rachel Harwood, MBBS
• Email: rachel.harwood@alderhey.nhs.uk
• Phone: 01512824998

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.