Exploring myelin repair in children with multiple sclerosis
Exploring Cortical Remyelination in Children With Multiple Sclerosis
NA · Assistance Publique - Hôpitaux de Paris · NCT05258396
This study is testing if new MRI techniques can help see if myelin repair happens in children with multiple sclerosis, to help find better treatments for them.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 12 Years to 18 Years |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris (other) |
| Locations | 3 sites (Le Kremlin-Bicêtre and 2 other locations) |
| Trial ID | NCT05258396 on ClinicalTrials.gov |
What this trial studies
This study investigates the potential for cortical remyelination in children diagnosed with multiple sclerosis (MS) using advanced MRI techniques. It aims to validate imaging methods that can measure myelin repair in vivo, addressing a significant gap in current pediatric MS research. The study will include children aged 12 to 18 years with relapsing-remitting MS and will assess their eligibility based on specific clinical criteria. By understanding the dynamics of myelin repair in this population, the research seeks to inform future therapeutic strategies.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 12 to 18 years diagnosed with relapsing-remitting multiple sclerosis.
Not a fit: Patients who have neurological conditions other than headaches or psychosomatic syndrome may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment options for children with multiple sclerosis.
How similar studies have performed: While there have been studies on adult MS patients, this approach focusing on pediatric patients and validating imaging techniques for remyelination is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria for patients : * age between 12 years old and 18 years old * RR-MS defined by 2017 McDonald criteria * no relapse the last 4 weeks * no methylprednisolone or prednisolone the last 4 weeks. * affiliated to the social security system * signature of the consent by the 2 holders of parental authority Inclusion Criteria for Volunteers: * age between 12 years old and 18 years old * absence of any neurological * signature of the consent by the 2 holders of parental authority Exclusion Criteria for both groups: * Parental rejection * Contre-indication of brain MRI: pace maker, tatoo of the face, claustrophobia…. * Pregnancy, copper intrauterine device
Where this trial is running
Le Kremlin-Bicêtre and 2 other locations
- Service de Neurologie Pédiatrique, Hôpital du Kremlin Bicêtre — Le Kremlin-Bicêtre, France (RECRUITING)
- CIC Neurosciences - Pitié Salpêtrière — Paris, France (RECRUITING)
- Service de Neurologie, GH Pitié Salpêtrière — Paris, France (NOT_YET_RECRUITING)
Study contacts
- Study coordinator: Elisabeth Maillart, MD, PH
- Email: elisabeth.maillart@aphp.fr
- Phone: 1 42 16 19 75
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Children With Multiple Sclerosis, MRI, MS