Exploring muscle protection in neuromuscular diseases through exercise
Repeated Bout Effect i Neuromuscular Diseases
NA · Rigshospitalet, Denmark · NCT05599568
This study is testing if doing one session of exercise can help protect muscles from damage during later workouts in people with neuromuscular diseases.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Rigshospitalet, Denmark (other) |
| Locations | 1 site (Copenhagen) |
| Trial ID | NCT05599568 on ClinicalTrials.gov |
What this trial studies
This study investigates the repeated bout effect (RBE) in patients with neuromuscular diseases (NMDs), focusing on whether a single bout of concentric exercise can protect against muscle damage from subsequent exercise. The research aims to understand how patients with NMDs respond to exercise, as they may experience significant muscle damage differently than healthy individuals. By utilizing serum biomarkers, muscle soreness assessments, and imaging techniques, the study will evaluate the protective effects of exercise in this population. The findings could inform future exercise protocols and treatment strategies for individuals with NMDs.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 with a molecular diagnosis of a specific neuromuscular condition who can complete the exercise challenge.
Not a fit: Patients with severe muscle weakness or concurrent medical conditions that interfere with exercise testing may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved exercise recommendations and rehabilitation strategies for patients with neuromuscular diseases.
How similar studies have performed: While the repeated bout effect has been well-documented in healthy individuals, this approach in patients with neuromuscular diseases is novel and has not been previously tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years * The ability to complete the exercise challenge * No concurrent medical condition that could interfere with interpretation of the results * Molecular diagnosis of the specific condition in specified patient groups or healthy control * No active muscle injury on the test day (caused by recent exercise, seizures, trauma, etc.) Exclusion Criteria: * Cardiac or pulmonary disease contraindicating peak exercise testing or strenuous exercise defined as NYHA-class III-IV * Veins that are too difficult to puncture for blood sampling, evaluated by the investigator * Severe muscle weakness, that prevents the subject completing the exercise test, evaluated by the investigator
Where this trial is running
Copenhagen
- Neuromuscular Research Unit, 3342 — Copenhagen, Denmark (RECRUITING)
Study contacts
- Study coordinator: Mads Stemmerik, MD
- Email: mads.peter.godtfeldt.stemmerik@regionh.dk
- Phone: +4535456126
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Myopathy